Study of Neutrophil-lymphocyte Ratio as Novel Marker for Diabetic Nephropathy in Type 2 Diabetes

Diabetic nephropathy (DN) is a microvascular complication of diabetes. DN is clinically manifested as an increase in urine albumin excretion. Total white blood cell count is a crude but sensitive indicator of inflammation and studied in many cardiac and noncardiac diseases as an inflammatory marker...

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Bibliographic Details
Published in:Indian journal of endocrinology and metabolism 2017-05, Vol.21 (3), p.387-392
Main Authors: Khandare, Sagar Ashokrao, Chittawar, Sachin, Nahar, Nitin, Dubey, T N, Qureshi, Zahraan
Format: Article
Language:English
Subjects:
Age
Alcohol
Blood
Body mass index
C-reactive protein
Care and treatment
Chronic illnesses
Complications and side effects
Diabetes
Diabetic nephropathies
Diabetic nephropathy
Diabetic neuropathy
Diabetic retinopathy
Heart attacks
Hospitals
Inflammation
Kidney diseases
Laboratories
Liver diseases
Lymphocytes
Medicine
Metabolism
Microscopy
microvascular
neutrophil-lymphocyte ratio
Neutrophils
Original
Risk factors
Tumor necrosis factor-TNF
Type 2 diabetes
Urinary tract infections
Urine
urine albumin
Viral infections
White blood cell count
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Summary:Diabetic nephropathy (DN) is a microvascular complication of diabetes. DN is clinically manifested as an increase in urine albumin excretion. Total white blood cell count is a crude but sensitive indicator of inflammation and studied in many cardiac and noncardiac diseases as an inflammatory marker such as acute myocardial infarction, stroke, and heart failure. In this study, the association of neutrophil-lymphocyte ratio (NLR) with DN is studied. It is an observational cross-sectional study. Totally 115 diagnosed type 2 diabetes mellitus patients were registered in this study. NLR was calculated by analyzing differential leukocyte count in complete blood picture. Albuminuria was tested by MICRAL-II TEST strips by dipstick method. Totally 115 diabetic patients were registered. About 56 patients had DN and 59 had normal urine albumin. Mean NLR for a normal group is 1.94 ± 0.65 and in DN group is 2.83 ± 0.85 which was highly significant ( < 0.001). Estimated glomerular filtration rate ( = 0.047) and serum glutamate pyruvate transaminase ( < 0.001) were also significant. The results of our study show that there was a significant relation between NLR and DN. Therefore, NLR may be considered as a novel surrogate marker of DN in early stages.
ISSN:2230-8210
2230-9500
DOI:10.4103/ijem.IJEM_476_16