A retrospective survey on the effectiveness of vaccines administered to individuals in China with regard to inactivated COVID-19 vaccines, Ad5-nCoV and/or aerosolized Ad5-nCoV

We administered a questionnaire to participants who received different vaccination regimens to evaluate the effectiveness of Ad5-vectored COVID-19 vaccines. The results showed that administration of intramuscular Ad5-nCoV provided 21.32% more protection against SARS-CoV-2 infection than that of the...

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Bibliographic Details
Published in:Emerging microbes & infections 2024-12, Vol.13 (1), p.2396875
Main Authors: Zhang, Zhe, Chi, Xiang-Yang, Zhang, Guan-Ying, Zhang, Zhang, Lu, Song-He, Li, Meng-Jing, Li, Liang-Jun, Zhang, Jin-Long, Shao, Fang-Ze, Zhang, Yue, Hou, Li-Hua, Chen, Wei
Format: Article
Language:English
Subjects:
Adenoviruses
Adult
aerosolized Ad5-nCoV
Aerosols
Aged
Antibodies, Viral - blood
Antibodies, Viral - immunology
Biotechnology
booster
China - epidemiology
COVID-19
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 vaccines
COVID-19 Vaccines - administration & dosage
COVID-19 Vaccines - immunology
Emerging and Re-Emerging Coronaviruses
Female
Humans
Immunization
Immunization, Secondary
Infections
Male
Middle Aged
mucosal
Questionnaires
relative effectiveness
Research Letter
Retrospective Studies
SARS-CoV-2 - immunology
Severe acute respiratory syndrome coronavirus 2
Surveys and Questionnaires
Vaccination
Vaccine Efficacy
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - immunology
Young Adult
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Description
Summary:We administered a questionnaire to participants who received different vaccination regimens to evaluate the effectiveness of Ad5-vectored COVID-19 vaccines. The results showed that administration of intramuscular Ad5-nCoV provided 21.32% more protection against SARS-CoV-2 infection than that of the inactivated COVID-19 vaccine in people who had received only one type of COVID-19 vaccine. Furthermore, aerosolized Ad5-nCoV exhibited good protection, whether it was administered as a homologous booster to people vaccinated with the intramuscular Ad5-nCoV or as a heterologous booster to people vaccinated with inactivated COVID-19 vaccines. Our research indicates that Ad5-nCoV is an effective booster. This finding supports the future selection of COVID-19 immunization strategies.
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2024.2396875