Development and Function of Protective and Pathologic Memory CD4 T Cells

Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses. Generated following an immune response, memory CD4 T cells retain pertinent information about...

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Bibliographic Details
Published in:Frontiers in immunology 2015-09, Vol.6, p.456-456
Main Authors: Jaigirdar, Shafqat Ahrar, MacLeod, Megan K L
Format: Article
Language:English
Subjects:
Autoimmunity
Cytokines
differentiation
epigenetics
Immunology
Memory
Vaccine
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Summary:Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses. Generated following an immune response, memory CD4 T cells retain pertinent information about their activation environment enabling them to make rapid effector responses upon reactivation. These responses can either benefit the host by hastening the control of pathogens or cause damaging immunopathology. Here, we will discuss the diversity of the memory CD4 T cell pool, the signals that influence the transition of activated T cells into that pool, and highlight how activation requirements differ between naïve and memory CD4 T cells. A greater understanding of these factors has the potential to aid the design of more effective vaccines and to improve regulation of pathologic CD4 T cells, such as in the context of autoimmunity and allergy.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2015.00456