Verruciform xanthoma: report of five cases

We describe five cases of verruciform xanthoma (VX). The patients, all males, presented with single warty verrucous lesions of 0.5-2 cm size that had been diagnosed clinically as viral warts (four cases) and leukoplakia (one case). Two patients had the lesion in the oral cavity, two on the genital m...

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Bibliographic Details
Published in:Indian journal of dermatology 2012-11, Vol.57 (6), p.479-482
Main Authors: Joshi, Rajiv, Ovhal, Ajay
Format: Article
Language:English
Subjects:
Care and treatment
Case Report
Case studies
Cervical cancer
Foam cells
Human papillomavirus
Infections
Lipids
Pathogenesis
verruciform xanthoma
viral wart
Warts
Xanthoma
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Description
Summary:We describe five cases of verruciform xanthoma (VX). The patients, all males, presented with single warty verrucous lesions of 0.5-2 cm size that had been diagnosed clinically as viral warts (four cases) and leukoplakia (one case). Two patients had the lesion in the oral cavity, two on the genital mucosa, and one on the scrotal skin. Histopathology was diagnostic, with verrucous and papillomatous epidermal hyperplasia with the silhouette of a viral wart but with numerous foamy histiocytes packed in the elongated dermal papillae. Columns of deep parakeratosis and neutrophils in the upper spinous layers, with a dermal plasma cell infiltrate were the other histopathologic findings. Excision of the lesions was curative, without recurrences, in the two patients who had lesions in the oral cavity; follow-up was not available in the cases with genital lesions. VX is an uncommon but distinctive clinicopathologic entity affecting the oral and genital mucosa that may be mistaken for benign, premalignant, and malignant conditions. VX can be diagnosed with certainty only on histopathologic examination.
ISSN:0019-5154
1998-3611
DOI:10.4103/0019-5154.103069