Impact of Coronary Artery Disease Severity Assessed With the SYNTAX Score on Outcomes Following Transcatheter Aortic Valve Replacement

Background The influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR. Methods...

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Bibliographic Details
Published in:Journal of the American Heart Association 2017-02, Vol.6 (2), p.n/a
Main Authors: Paradis, Jean‐Michel, White, Jonathon M., Généreux, Philippe, Urena, Marina, Doshi, Darshan, Nazif, Tamim, Hahn, Rebecca, George, Isaac, Khalique, Omar, Harjai, Kishore, Lasalle, Laura, Labbé, Benoit M., DeLarochellière, Robert, Doyle, Daniel, Dumont, Éric, Mohammadi, Siamak, Leon, Martin B., Rodés‐Cabau, Josep, Kodali, Susheel
Format: Article
Language:English
Subjects:
Aged, 80 and over
aortic stenosis
Aortic Valve Stenosis - complications
Aortic Valve Stenosis - diagnosis
Aortic Valve Stenosis - surgery
Cause of Death - trends
Coronary Angiography
coronary artery disease
Coronary Artery Disease - complications
Coronary Artery Disease - diagnosis
Coronary Artery Disease - mortality
Echocardiography
Female
Follow-Up Studies
Humans
Male
North America - epidemiology
Original Research
Percutaneous Coronary Intervention
Retrospective Studies
Severity of Illness Index
Survival Rate - trends
SYNTAX score
Time Factors
Transcatheter Aortic Valve Replacement
Treatment Outcome
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Summary:Background The influence of coronary artery disease (CAD) on clinical and echocardiographic outcomes after transcatheter aortic valve replacement (TAVR) is still controversial. We sought to evaluate the impact of CAD severity as measured by the SYNTAX score (SS) on patients undergoing TAVR. Methods and Results A total of 377 patients who underwent TAVR in 2 high‐volume centers in North America were included in our retrospective analysis. A blinded angiographic core laboratory calculated the SS on all available coronary angiograms with the use of quantitative coronary analysis. Patients were stratified into 4 groups: (1) no CAD (SS=0); (2) low SS (SS between 1 and 22); (3) intermediate SS (SS between 23 and 32); and (4) high SS (SS ≥33). Patients who had undergone percutaneous coronary intervention within 6 months prior to TAVR were separated into 2 categories based on their residual SS (
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.116.005070