Protective Biomolecular Mechanisms of Glutathione Sodium Salt in Ischemia-Reperfusion Injury in Patients with Acute Coronary Syndrome-ST-Elevation Myocardial Infarction

Ischemia-Reperfusion Injury (IRI) is responsible for adverse outcomes in patients with ST-Elevation Myocardial Infarction (STEMI). Oxidative stress, resulting from the production of Reactive Oxygen Species (ROS) and low availability of Glutathione (GSH), are the two main mediators of IRI. The effect...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-12, Vol.11 (24), p.3964
Main Authors: Arrivi, Alessio, Barillà, Francesco, Carnevale, Roberto, Sordi, Martina, Pucci, Giacomo, Tanzilli, Gaetano, Prandi, Francesca Romana, Mangieri, Enrico
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome
Amino acids
Analysis
Angioplasty
Animal models
Animals
Antioxidants
Antioxidants - therapeutic use
Cardiomyocytes
Care and treatment
Clinical outcomes
Complications and side effects
Diagnosis
Glutathione
Health aspects
Heart attack
Heart attacks
Homeostasis
Ischemia
Lymphocytes
Molecular mechanics
Mortality
Myocardial infarction
Myocardial Reperfusion Injury - drug therapy
Neutrophils
Oxidative stress
Prevention
primary PCI
Reactive oxygen species
Reperfusion
Reperfusion injury
Review
Risk factors
Sodium
ST Elevation Myocardial Infarction - drug therapy
STEMI
Vitamin E
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Summary:Ischemia-Reperfusion Injury (IRI) is responsible for adverse outcomes in patients with ST-Elevation Myocardial Infarction (STEMI). Oxidative stress, resulting from the production of Reactive Oxygen Species (ROS) and low availability of Glutathione (GSH), are the two main mediators of IRI. The effectiveness of exogenous antioxidant therapy in this scenario is still debated, since the encouraging results obtained in animal models have not been fully reproduced in clinical studies. In this review we focus on the role of GSH, specifically on the biomolecular mechanisms that preserve myocardial cells from damage due to reperfusion. In this regard, we provide an extensive discussion about GSH intrinsic antioxidant properties, its current applications in clinical practice, and the future perspectives.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11243964