COVID-19 Associated Rhino-Orbital Mucormycosis Complicated by Gangrenous and Bone Necrosis-A Case Report from Honduras

Mucormycosis is a life-threatening invasive fungal infection most commonly observed in immunocompromised patients. Throughout the COVID-19 pandemic, a growing number of associated infections, now termed COVID-19 associated mucormycosis (CAM), have been reported. Despite an increase in fatality repor...

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Bibliographic Details
Published in:Vaccines (Basel) 2021-07, Vol.9 (8), p.826
Main Authors: Palou, Elsa Yolanda, Ramos, María Auxiliadora, Cherenfant, Emec, Duarte, Adoni, Fuentes-Barahona, Itzel Carolina, Zambrano, Lysien I, Muñoz-Lara, Fausto, Montoya-Ramirez, Sandra Aracely, Cardona-Ortiz, Alex Francisco, Valle-Reconco, Jorge Alberto, Montenegro-Idrogo, Juan J, Bonilla-Aldana, D Katterine, Paniz-Mondolfi, Alberto E, Rodriguez-Morales, Alfonso J
Format: Article
Language:English
Subjects:
Amphotericin B
Bacterial infections
Biopsy
Case Report
Case reports
coinfection
Coronaviruses
COVID-19
Dexamethasone
Diabetes
Diabetes mellitus
Diagnosis
Drug dosages
Fungal infections
Fungi
Gangrene
Hematology
Immunocompromised hosts
Medical imaging
mucorales
Mucormycosis
Necrosis
opportunistic
Pandemics
Patients
Risk analysis
Risk factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Sinuses
Steroid hormones
Steroids
Surgery
Ulcers
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Summary:Mucormycosis is a life-threatening invasive fungal infection most commonly observed in immunocompromised patients. Throughout the COVID-19 pandemic, a growing number of associated infections, now termed COVID-19 associated mucormycosis (CAM), have been reported. Despite an increase in fatality reports, no cases of rhino-orbital CAM complicated with gangrenous bone necrosis have been described in the literature to date. A 56-year-old male with a recent COVID-19 diagnosis developed rhino-orbital mucormycosis after 22 days of treatment with dexamethasone. Cultures and histopathological assessment of tissue biopsy confirmed the diagnosis. The patient survived after treatment with amphotericin B. Mucormycosis is an invasive fungal infection affecting mostly immunocompromised patients. Along with the COVID-19 pandemic, the inappropriate use of steroids, in addition to concurrent risk factors, such as diabetes, has led to an increase in the occurrence of these devastating mycoses, leading to the development of severe presentations and complications, as observed in many cases. Early diagnosis and prompt treatment are crucial in order to avoid dissemination and fatal outcomes.
ISSN:2076-393X
2076-393X
DOI:10.3390/vaccines9080826