An archetype and scaling of developmental tissue dynamics across species

Morphometric studies have revealed the existence of simple geometric relationships among various animal shapes. However, we have little knowledge of the mathematical principles behind the morphogenetic dynamics that form the organ/body shapes of different species. Here, we address this issue by focu...

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Bibliographic Details
Published in:Nature communications 2023-12, Vol.14 (1), p.8199-8199, Article 8199
Main Authors: Morishita, Yoshihiro, Lee, Sang-Woo, Suzuki, Takayuki, Yokoyama, Hitoshi, Kamei, Yasuhiro, Tamura, Koji, Kawasumi-Kita, Aiko
Format: Article
Language:English
Subjects:
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Amphibians
Coordinates
Developmental stages
Dynamics
Humanities and Social Sciences
Introduced species
Linear transformations
Morphogenesis
multidisciplinary
Pattern formation
Patterning
Rescaling
Science
Science (multidisciplinary)
Spacetime
Synchronism
Synchronization
Tissues
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Summary:Morphometric studies have revealed the existence of simple geometric relationships among various animal shapes. However, we have little knowledge of the mathematical principles behind the morphogenetic dynamics that form the organ/body shapes of different species. Here, we address this issue by focusing on limb morphogenesis in Gallus gallus domesticus (chicken) and Xenopus laevis (African clawed frog). To compare the deformation dynamics between tissues with different sizes/shapes as well as their developmental rates, we introduce a species-specific rescaled spatial coordinate and a common clock necessary for cross-species synchronization of developmental times. We find that tissue dynamics are well conserved across species under this spacetime coordinate system, at least from the early stages of development through the phase when basic digit patterning is established. For this developmental period, we also reveal that the tissue dynamics of both species are mapped with each other through a time-variant linear transformation in real physical space, from which hypotheses on a species-independent archetype of tissue dynamics and morphogenetic scaling are proposed. Limb tissue dynamics until basic skeletal pattern establishment exhibit a high degree of conservation between chick and frog after proper rescaling of spacetime, suggesting the presence of a species-independent archetype of morphogenetic dynamics.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-43902-y