Prognostic significance of microvascular invasion in tumor stage for hepatocellular carcinoma

The presence of microvascular invasion (McVI) in hepatocellular carcinoma (HCC) has been proposed as a cause of recurrence and poor survival, although this has not been officially emphasized in staging systems. Thus, we conducted a retrospective study to investigate the prognostic importance of McVI...

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Bibliographic Details
Published in:World journal of surgical oncology 2017-12, Vol.15 (1), p.225-225, Article 225
Main Authors: Park, Yong Keun, Song, Sung Kyu, Kim, Bong-Wan, Park, Seung-Keun, Chung, Chul-Woon, Wang, Hee-Jung
Format: Article
Language:English
Subjects:
Alpha-fetoprotein
Development and progression
Hepatectomy
Hepatoma
Metastasis
Risk factors
Tumor node metastasis stage
Tumor recurrence
Tumor staging
Vascular invasion
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Summary:The presence of microvascular invasion (McVI) in hepatocellular carcinoma (HCC) has been proposed as a cause of recurrence and poor survival, although this has not been officially emphasized in staging systems. Thus, we conducted a retrospective study to investigate the prognostic importance of McVI in tumor staging in patients with HCC who underwent hepatic resection. A retrospective analysis was performed of patients who underwent hepatic resection for HCC at our center from 1994 to 2012. Patients with HCC were classified into four groups based on the presence of McVI and extent of gross vascular invasion (VI). The 5-year overall and recurrence-free survival rates of 676 patients were 63.3 and 42.6%, respectively. There was no difference in tumor recurrence or survival rate between patients with HCC and McVI without gross VI and those with gross VI confined to segmental/sectional branches. Multivariate analysis revealed that the extent of VI based on the presence of McVI and gross VI was independently associated with tumor recurrence and overall survival. McVI was revealed to be an important risk factor similar to gross VI confined to a segmental/sectional branch in patients with HCC who underwent hepatic resection. This finding should be considered when estimating the stage for prognosis.
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-017-1292-3