Bioaccessibility and Intestinal Transport of Tebuconazole in Table Grape by Using In Vitro Digestion Models

In this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is...

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Bibliographic Details
Published in:Foods 2022-12, Vol.11 (23), p.3926
Main Authors: Liu, Xiaowei, Han, Ying, Xiao, Ouli, Cui, Weiye, Chen, Jieyin, Dai, Xiaofeng, Li, Minmin, Kong, Zhiqiang
Format: Article
Language:English
Subjects:
bioaccessibility
Bioavailability
Caco-2 cells
Chemical properties
Chromatography
Colon
Dietary fiber
Dietary supplements
Digestion
Food
Food science
fungicide
Fungicides
grape
Grapes
Hazardous materials
Human body
in vitro model
Medical research
Medicine, Experimental
Methods
Pesticides
Pollutants
Pollution levels
Polyphenols
Reagents
Simulation
Tebuconazole
Vitaceae
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Summary:In this study, the effects of various digestive models, influencing factors and dietary supplements on the bioaccessibility of tebuconazole in table grapes were compared. The Caco-2 cell model was employed to reveal the transfer behavior of tebuconazole. The results indicated that digestion time is the main factor affecting bioaccessibility. With an increase in time, the tebuconazole in grapes was almost completely dissolved, with bioaccessibility reaching 98.5%, whereas dietary fiber reduced bioaccessibility. Tebuconazole undergoes carrier-free passive transport in permeable cells in the Caco-2 cell model. These findings have practical application value for correctly evaluating the harmful level of pollutants in the matrix to human body.
ISSN:2304-8158
2304-8158
DOI:10.3390/foods11233926