Impaired pulmonary and muscle function during moderate exercise in female patients recovered from SARS-CoV-2

• Published in: Scientific reports 2022-12, Vol.12 (1), p.20943-20943, Article 20943
• Main Authors: Pleguezuelos, Eulogio, Del Carmen, Amin, Moreno, Eva, Ortega, Pilar, Robles, Alejandro, Serra-Prat, Mateo, Miravitlles, Marc, Yebenes, Joan Carles, Garnacho-Castaño, Manuel V.
• Format: Article
• Language: English
• Subjects: 631/443; 631/443/1784; 692/699/1785; Adult; Coronaviruses; COVID-19; Efficiency; Exercise; Exercise Test; Female; Humanities and Social Sciences; Humans; multidisciplinary; Muscles; Oxygen uptake; SARS-CoV-2; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-24941-9

This study aimed to assess pulmonary and muscle dysfunction by analyzing the slow component of oxygen uptake (VO 2SC ), and mechanical and ventilatory efficiency in adult women recovered from the severe acute respiratory syndrome coronavirus type II (SARS-CoV-2) during a constant load test. 32 women (N = 17 patients with SARS-CoV-2; N = 15 control group) performed two cardiopulmonary exercise tests (CPX) on a cycle ergometer. In the first test, the participants performed incremental CPX until extenuation. In the second test the participants performed a 10-min CPX at a constant load intensity (watts) corresponding to the first ventilatory threshold. There was a 48–72 h rest period between the two tests. There was a significant increase in the VO 2SC in the patients recovered from SARS-CoV-2 (160.4 ± 60 mL min −1 ) in comparison with the healthy participants (59.6 ± 65 mL min −1 ) ( P