Emerging advances in identifying signal transmission molecules involved in the interaction between Mycobacterium tuberculosis and the host

Tuberculosis caused by Mycobacterium tuberculosis (MTB) is an ancient chronic infectious disease and is still the leading cause of death worldwide due to a single infectious disease. MTB can achieve immune escape by interacting with host cells through its special cell structure and secreting a varie...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2022-07, Vol.12, p.956311-956311
Main Authors: Wang, Yue, Shi, Qiyuan, Chen, Qi, Zhou, Xuebin, Yuan, Huiling, Jia, Xiwen, Liu, Shuyuan, Li, Qin, Ge, Lijun
Format: Article
Language:English
Subjects:
Cellular and Infection Microbiology
chronic infectious disease
immune escape
innate immunity
Mycobacterium tuberculosis
signaling pathway
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Tuberculosis caused by Mycobacterium tuberculosis (MTB) is an ancient chronic infectious disease and is still the leading cause of death worldwide due to a single infectious disease. MTB can achieve immune escape by interacting with host cells through its special cell structure and secreting a variety of effector proteins. Innate immunity-related pattern recognition receptors (PPR receptors) play a key role in the regulation of signaling pathways. In this review, we focus on the latest research progress on related signal transduction molecules in the interaction between MTB and the host. In addition, we provide new research ideas for the development of new anti-tuberculosis drug targets and lead compounds and provide an overview of information useful for approaching future tuberculosis host-oriented treatment research approaches and strategies, which has crucial scientific guiding significance and research value.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2022.956311