Self-expandable metallic stenting as a bridge to elective surgery versus emergency surgery for acute malignant right-sided colorectal obstruction

• Published in: BMC surgery 2020-12, Vol.20 (1), p.326-326, Article 326
• Main Authors: Li, Bing, Cai, Shi-Lun, Lv, Zhen-Tao, Zhou, Ping-Hong, Yao, Li-Qing, Shi, Qiang, Qi, Zhi-Peng, Sun, Di, Yalikong, Ayimukedisi, Xu, En-Pan, Xu, Jian-Min, Zhong, Yun-Shi
• Format: Article
• Language: English
• Subjects: Abdomen; Adult; Aged; Aged, 80 and over; Blocking; Blood tests; Cancer patients; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Colon; Colon cancer; Colonoscopy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - complications; Colorectal Neoplasms - surgery; Comparative analysis; Complications; Elective surgery; Elective Surgical Procedures; Female; Gastrointestinal diseases; Hepatectomy; Hospitals; Humans; Implants; Intestinal obstruction; Intestinal Obstruction - surgery; Liver; Liver cancer; Liver metastases; Liver Neoplasms - complications; Liver Neoplasms - surgery; Male; Metastases; Metastasis; Middle Aged; Mortality; Obstruction; Ostomy; Patients; Postoperative period; Prognosis; Retrospective Studies; Right-sided colon cancer; Self-expandable metallic stent; Stent (Surgery); Stents; Surgery; Survival; Treatment Outcome; Tumors; Ultrasonic imaging; Young Adult
• ISSN: 1471-2482; 1471-2482
• DOI: 10.1186/s12893-020-00993-4

The use of a self-expandable metallic stent (SEMS) as a bridge to surgery has increased for patients with obstructing colorectal cancer. However, relatively few reports have compared SEMS as a bridge to elective surgery for acute malignant obstruction of the right-sided colon (MORC) vs. emergency surgery (ES). This study aimed to evaluate the benefits of elective surgery after SEMS placement vs. ES for patients (including stage IV cases) with acute MORC. Patients with acute MORC who underwent radical resection for a primary tumour from July 2008 to November 2016 at Zhongshan Hospital of Fudan University were retrospectively enrolled. Postoperative short-term outcomes, progression-free survival (PFS), and overall survival (OS) were compared between the SEMS and ES groups. In total, 107 patients with acute MORC (35 in the SEMS group and 72 in the ES group) were included for analysis. The Intensive Care Unit admission rate was lower (11.4% vs. 34.7%, P = 0.011), the incidence of complications was reduced (11.4% vs. 29.2%, P = 0.042), and the postoperative length of hospitalisation was significantly shorter (8.23 ± 6.50 vs. 11.18 ± 6.71 days, P = 0.033) for the SEMS group. Survival curves showed no significant difference in PFS (P = 0.506) or OS (P = 0.989) between groups. Also, there was no significant difference in PFS and OS rates between patients with stage II and III colon cancer. After colectomy for synchronous liver metastases among stage IV patients, the hepatectomy rates for the SEMS and ES groups were 85.7% and 14.3%, respectively (P = 0.029). The hazard ratio for colectomy alone vs. combined resection was 3.258 (95% CI 0.858-12.370; P = 0.041). Stent placement offers significant advantages in terms of short-term outcomes and comparable prognoses for acute MORC patients. For synchronous liver metastases, SEMS placement better prepares the patient for resection of the primary tumour and liver metastasis, which contribute to improved survival.