Clinical, Pathological and Molecular Characteristics of Chilean Patients with Early-, Intermediate- and Late-Onset Colorectal Cancer

Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patie...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2021-03, Vol.10 (3), p.631
Main Authors: Alvarez, Karin, Cassana, Alessandra, De La Fuente, Marjorie, Canales, Tamara, Abedrapo, Mario, López-Köstner, Francisco
Format: Article
Language:English
Subjects:
Age
age of onset
Body mass index
Cancer
cancer diagnosis
Colorectal cancer
Colorectal carcinoma
Consent
Diagnosis
Family medical history
germ-line mutations
Medical prognosis
Microsatellite instability
Mortality
Mutation
Survival
Tumors
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Summary:Colorectal cancer (CRC) is the second most frequent neoplasm in Chile and its mortality rate is rising in all ages. However, studies characterizing CRC according to the age of onset are still lacking. This study aimed to identify clinical, pathological, and molecular features of CRC in Chilean patients according to the age of diagnosis: early- (≤50 years; EOCRC), intermediate- (51-69 years; IOCRC), and late-onset (≥70 years; LOCRC). The study included 426 CRC patients from Clinica Las Condes, between 2007 and 2019. A chi-square test was applied to explore associations between age of onset and clinicopathological characteristics. Body Mass Index (BMI) differences according to age of diagnosis was evaluated through t-test. Overall (OS) and cancer-specific survival (CSS) were estimated by the Kaplan-Meier method. We found significant differences between the age of onset, and gender, BMI, family history of cancer, TNM Classification of Malignant Tumors stage, OS, and CSS. EOCRC category was characterized by a family history of cancer, left-sided tumors with a more advanced stage of the disease but better survival at 10 years, and lower microsatellite instability (MSI), with predominant germline mutations. IOCRC has shown clinical similarities with the EOCRC and molecular similarities to the LOCRC, which agrees with other reports.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells10030631