Sex-specific association between platelet content and bone mineral density in adults: a cross-sectional study

• Published in: BMC musculoskeletal disorders 2024-11, Vol.25 (1), p.875-9, Article 875
• Main Authors: Zhang, Yucheng, Zhao, Bofan, Huang, Zhendong, Xie, Juan, Zhou, Xinli, Fan, Chanyang, Chen, Meng, Yan, Lixiang, Shi, Zhexin
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Analysis; Blood; Blood cell count; Blood Platelets; Blood tests; Body mass index; Bone density; Bone Density - physiology; Bone growth; Bone marrow; Bone mass; Bone mineral content; Bone mineral density; Bone remodeling; Bone resorption; Bones; Care and treatment; Creatinine; Cross-Sectional Studies; Cross-sectional study; Density; Diagnosis; Female; Females; Fractures; Gender; Health aspects; Health surveys; Hemoglobin; Humans; Investigations; Male; Medical examination; Middle Aged; NHANES; Nutrition Surveys; Osteogenesis; Osteoporosis; Osteoporosis - blood; Osteoporosis - epidemiology; Overweight; Platelet; Platelet content; Platelet Count; Platelets; Population; Population studies; Regression analysis; Review boards; Risk Factors; Sex Factors; Smoking; Thrombocytopenia; United States - epidemiology; Variables; Vigilance; Young Adult
• ISSN: 1471-2474; 1471-2474
• DOI: 10.1186/s12891-024-07963-4

Osteoporosis (OP) is a complex skeletal disorder characterized by reduced bone mass, microarchitectural deterioration of bone tissue, and increased susceptibility to fractures. Bone mineral density (BMD), as the best indicator of bone mineral content per unit area of bone, is one of the key diagnostic factors for OP. Platelets (PLT), serving as important immune cells and components of the coagulation system, have been demonstrated to be associated with bone formation, resorption, and remodeling processes. However, no research has established the relationship between BMD and platelet count (PC) in the American population thus far. This study aims to investigate the correlation between BMD and PC among the American population, and to appraise the effects of additional risk factors on this association. This investigation examined the relationship between BMD and PC by analyzing data from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2018. A weighted multivariate logistic regression analysis was employed to assess this correlation. Additionally, subgroup and smooth curve analyses were conducted to delve deeper into the BMD-PC relationship and to identify other potential determinants of PC. This study reveals a significant negative correlation between BMD and PC in the American adult population (β=-15.05, 95% CI: -22.07 to -8.03, p