Accuracy of the urine point-of-care circulating cathodic antigen assay for diagnosing Schistosomiasis mansoni infection in Brazil: A multicenter study

The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in...

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Bibliographic Details
Published in:Revista da Sociedade Brasileira de Medicina Tropical 2023-01, Vol.56
Main Authors: Pieri, Otavio Sarmento, Bezerra, Fernando Schemelzer Moraes, Coelho, Paulo Marcos Zech, Enk, Martin Johannes, Favre, Tereza Cristina, Graeff-Teixeira, Carlos, Oliveira, Ricardo Riccio, Reis, Mitermayer Galvão Dos, Andrade, Lee Senhorinha de Almeida, Beck, Lilian Christina Nóbrega Holsbach, Favero, Vivian, Fialho, Thainá Rodrigues de Souza, Guimarães, Ricardo José de Paula Souza E, Oliveira, Bruna Souza Santos, Pascoal, Vanessa Fey, Pinheiro, Marta Cristhiany Cunha, Santos, Ronald Alves Dos, Silva, Luciano Kalabric, Siqueira, Isadora Cristina de, Souza, Renata Perotto de, Katz, Naftale
Format: Article
Language:English
Subjects:
Animals
Antigens, Helminth - urine
Brazil
Brazil - epidemiology
Circulating cathodic antigen (CCA)
Feces
Helmintex
Humans
Kato-Katz
Point-of-care (POC)
Point-of-Care Systems
Prevalence
Schistosoma mansoni
Schistosomiasis mansoni - diagnosis
Schistosomiasis mansoni - epidemiology
Sensitivity and Specificity
Short Communication
TROPICAL MEDICINE
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Summary:The World Health Organization recommends a market-ready, urine-based point-of-care diagnostic test for circulating cathodic antigens (CCA) to determine the prevalence of S. mansoni. This study evaluated the performance of the URINE CCA (SCHISTO) ECO TESTE® (POC-ECO), which is currently available in Brazil. Residents from eight sites with different prevalence estimates provided one urine sample for POC-ECO and one stool sample for Kato-Katz (KK) and Helmintex® (HTX) testing as an egg-detecting reference for infection status. None of the study sites had significantly higher POC-ECO accuracy than KK. POC-ECO is not currently recommended in Brazilian schistosomiasis elimination programs.
ISSN:0037-8682
1678-9849
1678-9849
DOI:10.1590/0037-8682-0238-2022