Effects of selective heart rate reduction with ivabradine on LV function and central hemodynamics in patients with chronic coronary syndrome

We assessed left ventricular (LV) function and central hemodynamic effects in patients with a heart rate (HR) at rest of ≥70 beats per minute (bpm) and chronic coronary syndrome (CCS) after long-term treatment with ivabradine compared to placebo by cardiac magnetic resonance (CMR) imaging. In a rand...

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Bibliographic Details
Published in:International journal of cardiology. Heart & vasculature 2021-06, Vol.34, p.100757, Article 100757
Main Authors: Hohneck, Anna Lena, Fries, Peter, Stroeder, Jonas, Schneider, Günther, Schirmer, Stephan Henrik, Reil, Jan-Christian, Böhm, Michael, Laufs, Ulrich, Custodis, Florian
Format: Article
Language:English
Subjects:
Arterial stiffness
Chronic coronary syndrome
Heart rate reduction
Hemodynamics
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Summary:We assessed left ventricular (LV) function and central hemodynamic effects in patients with a heart rate (HR) at rest of ≥70 beats per minute (bpm) and chronic coronary syndrome (CCS) after long-term treatment with ivabradine compared to placebo by cardiac magnetic resonance (CMR) imaging. In a randomized, double-blinded, prospective cross-over design, 23 patients (18 male, 5 female) were treated with ivabradine (7.5 mg bid) or placebo for 6 months. CMR imaging was performed at baseline and after 6 and 12 months to determine LV functional parameters. Mean resting HR on treatment with ivabradine was 58 ± 8.2 bpm and 70.2 ± 8.3 bpm during placebo (p 
ISSN:2352-9067
2352-9067
DOI:10.1016/j.ijcha.2021.100757