Meniscus Regeneration With Multipotent Stromal Cell Therapies

Meniscus is a semilunar wedge-shaped structure with fibrocartilaginous tissue, which plays an essential role in preventing the deterioration and degeneration of articular cartilage. Lesions or degenerations of it can lead to the change of biomechanical properties in the joints, which ultimately acce...

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Bibliographic Details
Published in:Frontiers in bioengineering and biotechnology 2022-02, Vol.10, p.796408-796408
Main Authors: Zhou, Yun-Feng, Zhang, Di, Yan, Wan-Ting, Lian, Kai, Zhang, Zheng-Zheng
Format: Article
Language:English
Subjects:
Bioengineering and Biotechnology
biotherapy
meniscus repair
mesenchymal stem cell
regenerative medicine
tissue engineering
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Summary:Meniscus is a semilunar wedge-shaped structure with fibrocartilaginous tissue, which plays an essential role in preventing the deterioration and degeneration of articular cartilage. Lesions or degenerations of it can lead to the change of biomechanical properties in the joints, which ultimately accelerate the degeneration of articular cartilage. Even with the manual intervention, lesions in the avascular region are difficult to be healed. Recent development in regenerative medicine of multipotent stromal cells (MSCs) has been investigated for the significant therapeutic potential in the repair of meniscal injuries. In this review, we provide a summary of the sources of MSCs involved in repairing and regenerative techniques, as well as the discussion of the avenues to utilizing these cells in MSC therapies. Finally, current progress on biomaterial implants was reviewed.
ISSN:2296-4185
2296-4185
DOI:10.3389/fbioe.2022.796408