NEUROlogical Prognosis After Cardiac Arrest in Kids (NEUROPACK) study: protocol for a prospective multicentre clinical prediction model derivation and validation study in children after cardiac arrest

IntroductionCurrently, we are unable to accurately predict mortality or neurological morbidity following resuscitation after paediatric out of hospital (OHCA) or in-hospital (IHCA) cardiac arrest. A clinical prediction model may improve communication with parents and families and risk stratification...

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Published in:BMJ open 2020-09, Vol.10 (9), p.e037517-e037517
Main Authors: Scholefield, Barnaby Robert, Martin, James, Penny-Thomas, Kate, Evans, Sarah, Kool, Mirjam, Parslow, Roger, Feltbower, Richard, Draper, Elizabeth S, Hiley, Victoria, Sitch, Alice J, Kanthimathinathan, Hari Krishnan, Morris, Kevin P, Smith, Fang
Format: Article
Language:English
Subjects:
Adolescent
Audits
Cardiac arrest
Cardiopulmonary Resuscitation
Child
Communication
CPR
Critical care
Data collection
Epidemiology
Families & family life
Heart attacks
Humans
Infant, Newborn
Informed consent
Intensive Care
Ireland - epidemiology
Medical prognosis
Models, Statistical
Mortality
Multicenter Studies as Topic
Ostomy
Out-of-Hospital Cardiac Arrest - therapy
Parents & parenting
Patients
Pediatrics
Prognosis
Prospective Studies
Validation studies
Variables
Wales
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Summary:IntroductionCurrently, we are unable to accurately predict mortality or neurological morbidity following resuscitation after paediatric out of hospital (OHCA) or in-hospital (IHCA) cardiac arrest. A clinical prediction model may improve communication with parents and families and risk stratification of patients for appropriate postcardiac arrest care. This study aims to the derive and validate a clinical prediction model to predict, within 1 hour of admission to the paediatric intensive care unit (PICU), neurodevelopmental outcome at 3 months after paediatric cardiac arrest.Methods and analysisA prospective study of children (age: >24 hours and
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2020-037517