Early Perturbations in Glucose Utilization in Malaria-Infected Murine Erythrocytes, Liver and Brain Observed by Metabolomics

Investigation of glucose utilization during an infection is central to the study of energy metabolism. The heavy utilization of glucose by the malaria parasite, and the consequences of this process, have been investigated extensively. However, host glucose utilization during early infection has not...

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Bibliographic Details
Published in:Metabolites 2020-07, Vol.10 (7), p.277
Main Authors: Sengupta, Arjun, Ghosh, Soumita, Sharma, Shobhona, Sonawat, Haripalsingh M.
Format: Article
Language:English
Subjects:
13C NMR
Acidosis
Animals
Balb/c
Discriminant analysis
Energy metabolism
Erythrocytes
Fatty acids
Glucose
Glucose metabolism
glucose utilization
Glycolysis
Hypoglycemia
Infections
Labeling
Liver
Magnetic resonance spectroscopy
Malaria
Metabolic pathways
Metabolism
Metabolites
Metabolomics
NMR
Nuclear magnetic resonance
Parasitemia
Parasites
Plasmodium berghei ANKA
Principal components analysis
Spectrum analysis
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Summary:Investigation of glucose utilization during an infection is central to the study of energy metabolism. The heavy utilization of glucose by the malaria parasite, and the consequences of this process, have been investigated extensively. However, host glucose utilization during early infection has not been explored to date. In a first attempt, this article investigates the changes in the host glucose utilization in Balb/c mice infected with Plasmodium berghei ANKA using 13C-labeled glucose infusion followed by NMR spectroscopy. The results suggested significant alterations of liver, brain and red blood cell (RBC) glucose utilization during early infection when the parasitemia was
ISSN:2218-1989
2218-1989
DOI:10.3390/metabo10070277