Prolonged Survival of Acute Lymphoblastic Leukemia with Intrathecal Treatments for Isolated Central Nervous System Relapse

Acute lymphoblastic leukemia is commonly cured when diagnosed in the pediatric population. It portends a poorer prognosis if present in adult patients. Although adults frequently achieve complete remission, relapse rates are substantial, particularly among the elderly and high-risk populations. In t...

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Bibliographic Details
Published in:Case reports in hematology 2018-01, Vol.2018 (2018), p.1-3
Main Authors: Gorshein, Elan, Gharibo, Mecide, Kalathil, Sheila
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
Blood
Bone marrow
Cancer
Cancer therapies
Case Report
Case reports
Cellular biology
Chemotherapy
Diagnosis
Diseases
Drug therapy
Family medical history
Flow cytometry
Hematology
Leukemia
Medical prognosis
Nervous system
Patients
Quality of life
Relapse
Stem cells
Studies
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Description
Summary:Acute lymphoblastic leukemia is commonly cured when diagnosed in the pediatric population. It portends a poorer prognosis if present in adult patients. Although adults frequently achieve complete remission, relapse rates are substantial, particularly among the elderly and high-risk populations. In the absence of prophylactic intrathecal chemotherapy, more than half of patients may develop CNS involvement or relapse, which is associated with significant risk for systemic illness. This report describes a patient with acute lymphoblastic leukemia with repeated isolated CNS relapses. This case should remind clinicians that isolated CNS disease in the absence of systemic recurrence could successfully respond to intrathecal therapy and offer patients a favorable quality of life.
ISSN:2090-6560
2090-6579
DOI:10.1155/2018/8765285