The systemic evaluation and clinical significance of immunological function for advanced lung cancer patients

• Published in: Zhongguo fei ai za zhi 2010-04, Vol.13 (4), p.331-336
• Main Authors: Wulan, Tuya, Wang, Shiyong, Du, Weili, Zhang, Hui, Zhang, Yuan, Zeng, Xue, Liu, Sa, Liu, Yanping, Zhang, Lu, Zhang, Zhe, He, Ying, Wang, Jialing, Wu, Xiuyan
• Format: Article
• Language: Chinese
• Subjects: Adult; Aged; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cell immunity; Cell Line, Tumor; Cytokine; Female; Flow Cytometry; Granzymes - metabolism; Humans; Humoral immunity; Interferon-gamma - metabolism; Interleukin-4 - metabolism; Lung neoplasms; Lung Neoplasms - immunology; Lung Neoplasms - pathology; Male; Middle Aged; Perforin - metabolism; Regulatary T cells
• ISSN: 1009-3419; 1999-6187
• DOI: 10.3779/j.issn.1009-3419.2010.04.12

The actual evaluation of immunological function is significant for studing the tumor development and devising a treatment in time. The aim of this study is to evaluate the immunological function of advanced lung cancer patients systematically, and to discuss the clinical significance. The nucleated cell amounts of advanced lung cancer patients and the healthy individuals were counted. The immune cell subsets and the levels of IL-4, INF-gamma, perforin and granzyme in CD8+T cells by the flow cytometry were measured. The proliferation activity and the inhibition ratio of immune cells to several tumor cell lines were evaluated by MTT assay. The absolute amounts and subsets of T, B, NK cells of advanced lung cancer patients were lower than the healthy individuals (P < 0.05); However, the proportion of regulatory T cells of advanced lung cancer patients (4.00 +/- 1.84)% was lower than the healthy individuals (1.27 +/- 0.78)% (P < 0.05). The positive rates of IFN-gamma perforin, granzyme in CD8+T cells decreased wh