Germline cells in ovarian surface epithelium of mammalians: a promising notion

It is a long held doctrine in reproductive biology that women are born with a finite number of oocytes and there is no oogenesis during the postnatal period. However, recent evidence challenges this by showing the presence of germ line stem cells in the human ovarian surface epithelium (OSE), which...

Full description

Saved in:
Bibliographic Details
Published in:Reproductive biology and endocrinology 2012-12, Vol.10 (1), p.112-112
Main Authors: Celik, Onder, Celik, Ebru, Turkcuoglu, Ilgin, Yilmaz, Ercan, Simsek, Yavuz, Tiras, Bulent
Format: Article
Language:English
Subjects:
Animals
Biomarkers - metabolism
Bone marrow
Epithelial Cells - cytology
Epithelial Cells - metabolism
Epithelium
Epithelium - metabolism
Female
Genetic aspects
Germ Cells - cytology
Germ Cells - metabolism
Germ line cells
Human
Humans
Ionizing radiation
Mammals
Medical research
Oocyte-like cells
Oocytes - cytology
Oocytes - metabolism
Ovarian surface epithelium
Ovaries
Ovary - cytology
Ovary - metabolism
Pluripotency
Proteins
Review
Rodents
Stem cell research
Stem cells
Stem Cells - cytology
Stem Cells - metabolism
Studies
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It is a long held doctrine in reproductive biology that women are born with a finite number of oocytes and there is no oogenesis during the postnatal period. However, recent evidence challenges this by showing the presence of germ line stem cells in the human ovarian surface epithelium (OSE), which can serve as a source of germ cells, and differentiate into oocyte like structures. Postnatal renewal of oocytes may have enormous therapeutic potential especially in women facing the risk of premature ovarian failure idiopathically or iatrogenically after exposure to gonadotoxic chemotherapy and radiation for cancer therapy.This article reviews current knowledge on germ line stem cells in human OSE.
ISSN:1477-7827
1477-7827
DOI:10.1186/1477-7827-10-112