The positive effect of eugenol on acute pancreatic tissue injury: a rat experimental model

we present a rat experimental model used to evaluate the possible reduction in the extent of pancreatic tissue injury in acute pancreatitis cases, after administration of eugenol. one hundred and twenty Wistar rats were used, which were randomly assigned in 3 groups: sham (n=20), control (n=50) and...

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Bibliographic Details
Published in:The Pan African medical journal 2021, Vol.38 (132), p.132-132
Main Authors: Tsaroucha, Alexandra, Kaldis, Vasileios, Vailas, Michail, Schizas, Dimitrios, Lambropoulou, Maria, Papalois, Apostolos, Tsigalou, Christina, Gaitanidis, Apostolos, Pitiakoudis, Michael, Simopoulos, Constantinos
Format: Article
Language:English
Subjects:
Abdomen
Acute Disease
acute pancreatitis
Animals
Antibodies
Catheters
Disease Models, Animal
eugenol
Eugenol - pharmacology
Free Radical Scavengers - pharmacology
histopathological evaluation
immunohistochemistry
Intubation
Laboratories
Male
Mortality
Multiple organ dysfunction syndrome
Neutrophils
Pancreas - drug effects
Pancreas - enzymology
Pancreatitis
Pancreatitis - prevention & control
Peroxidase - metabolism
rat experimental model
Rats
Rats, Wistar
Sepsis
Tumor necrosis factor-TNF
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Summary:we present a rat experimental model used to evaluate the possible reduction in the extent of pancreatic tissue injury in acute pancreatitis cases, after administration of eugenol. one hundred and twenty Wistar rats were used, which were randomly assigned in 3 groups: sham (n=20), control (n=50) and eugenol (n=50). Acute pancreatitis was induced by biliopancreatic ligation in the control and eugenol groups, but not in the Sham group. In the eugenol group, eugenol was administered per-os. Five histopathological parameters, such as edema, inflammatory infiltration, duct dilatation, hemorrhage and acinar necrosis were evaluated. at 72 h from acute pancreatitis induction, the total histological score was diminished in the eugenol group (p
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2021.38.132.20202