A Turbidity Test Based Centrifugal Microfluidics Diagnostic System for Simultaneous Detection of HBV, HCV, and CMV

This paper presents a LAMP- (loop-mediated isothermal amplification-) based lab-on-disk optical system that allows the simultaneous detection of hepatitis B virus, hepatitis C virus, and cytomegalovirus. The various flow stages are controlled in the proposed system using different balance among cent...

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Bibliographic Details
Published in:Advances in materials science and engineering 2015-01, Vol.2015 (2015), p.1-8
Main Authors: Lee, Jiun-Haw, Lin, Chii-Wann, Liu, Kou-Chen, Ho, Bing-Ching, Lee, Chun-Nan, Yu, Ya-Lin, Yen, Jia-Yush, Chao, Yu-Tin, Chang, Hung-Cheng, Fang, Jiunn
Format: Article
Language:English
Subjects:
Automation
Centrifugal pumps
Coriolis force
Cytomegalovirus
Deoxyribonucleic acid
Design
Diagnostic systems
DNA
Engineering
Enzymes
Genetic testing
Heating
Hepatitis B virus
Hepatitis C virus
Influenza
Microfluidics
Optical pumping
Servocontrol
Severe acute respiratory syndrome
Turbidity
Viruses
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Summary:This paper presents a LAMP- (loop-mediated isothermal amplification-) based lab-on-disk optical system that allows the simultaneous detection of hepatitis B virus, hepatitis C virus, and cytomegalovirus. The various flow stages are controlled in the proposed system using different balance among centrifugal pumping, Coriolis pumping, and the capillary force. We have implemented a servo system for positioning and speed control for the heating and centrifugal pumping. We have also successfully employed a polymer light-emitting diode section for turbidity detection. The easy-to-use one-click system can perform diagnostics in less than 1 hour.
ISSN:1687-8434
1687-8442
DOI:10.1155/2015/306708