SNP mutation‐related genes in breast cancer for monitoring and prognosis of patients: A study based on the TCGA database

• Published in: Cancer medicine (Malden, MA) MA), 2019-05, Vol.8 (5), p.2303-2312
• Main Authors: Gao, Chundi, Zhuang, Jing, Zhou, Chao, Li, Huayao, Liu, Cun, Liu, Lijuan, Feng, Fubin, Liu, Ruijuan, Sun, Changgang
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; AKT protein; AKT1 protein; Bioinformatics; bioinformatics analysis; Biomarkers; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; Breast Neoplasms - diagnosis; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Cancer Biology; Correlation analysis; Data processing; Databases, Genetic; Deoxyribonucleic acid; DNA; DNA methylation; DNA repair; E-cadherin; Early Detection of Cancer; Female; Gastric cancer; GATA-3 protein; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genomes; Humans; Invasiveness; MAP kinase; Medical prognosis; Metastases; MicroRNAs - genetics; miRNA; Mutation; Original Research; Ovarian cancer; Polymorphism, Single Nucleotide; Prognosis; Protein Interaction Maps; PTEN protein; Quality of life; Sequence Analysis, DNA - methods; Signal Transduction; single nucleotide polymorphisms; Single-nucleotide polymorphism; Software; Studies; Survival; Survival Analysis
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.2065

Advances in cancer biology have allowed early diagnosis and more comprehensive treatment of breast cancer (BC). However, it remains the most common cause of cancer death in women worldwide because of its strong invasiveness and metastasis. In‐depth study of the molecular pathogenesis of BC and of relevant prognostic markers would improve the quality of life and prognosis of patients. In this study, bioinformatics analysis of SNP‐related data from BC patients provided in the TCGA database revealed that six mutant genes (NCOR1, GATA3, CDH1, ATM, AKT1, and PTEN) were significantly associated with the corresponding expression levels of the proteins. The proteins were involved in multiple pathways related to the development of cancer, including the PI3K‐Akt signaling pathway, pertinent microRNAs, and the MAPK signaling pathway. In addition, overall survival and recurrence‐free survival analysis revealed the close associations of the expression of GATA3, NCOR1, CDH1, and ATM with survival of BC patients. Therefore, detecting these gene mutations and exploring their corresponding expression could be valuable in predicting the prognosis of patients. The results of the high‐throughput data mining provide important fundamental bioinformatics information and a relevant theoretical basis for further exploring the molecular pathogenesis of BC and assessing the prognosis of patients. In‐depth study of the molecular pathogenesis of breast cancer (BC) and of relevant prognostic markers would improve the quality of life and prognosis of patients. In this study, bioinformatics analysis revealed that six mutant genes were significantly associated with the corresponding expression levels of the proteins. In addition, Kaplan‐Meier survival curve analysis revealed the close associations of the expression of GATA3, NCOR1, CDH1, and ATM with survival of BC patients. Therefore, detecting these gene mutations and exploring their corresponding expression could be valuable in predicting the prognosis of patients.