Synthesis and evaluation of platinum complexes with potential antitumor activity

A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromola...

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Bibliographic Details
Published in:Brazilian Journal of Pharmaceutical Sciences 2017-01, Vol.53 (1)
Main Authors: Freire, Rachel Lima Marcelino, Marques, Maria Betânia de Freitas, Souza-Fagundes, Elaine Maria de, Oliveira, Renata Barbosa de, Alves, Ricardo José
Format: Article
Language:English
Subjects:
Aqueous solutions
Caustic soda
Cytotoxic activity
Deoxyribonucleic acid
DNA
Ligands
PHARMACOLOGY & PHARMACY
Platinum complexes/ Ehrlich solid tumor activity
Solvents
Testicular cancer
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Summary:A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice with Ehrlich solid tumors and it was able to reduce the rate of tumor growth significantly during the first seven days. However, at the end of the experiments, there was no significant difference between the group of animals treated with 3 and the control group. The low solubility of the compound in the assay conditions can explain, at least in part, these results.
ISSN:1984-8250
2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902017000115235