Synthesis and evaluation of platinum complexes with potential antitumor activity

A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromola...

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Published in:Brazilian Journal of Pharmaceutical Sciences 2017-01, Vol.53 (1)
Main Authors: Freire, Rachel Lima Marcelino, Marques, Maria Betânia de Freitas, Souza-Fagundes, Elaine Maria de, Oliveira, Renata Barbosa de, Alves, Ricardo José
Format: Article
Language:English
Subjects:
Aqueous solutions
Caustic soda
Cytotoxic activity
Deoxyribonucleic acid
DNA
Ligands
PHARMACOLOGY & PHARMACY
Platinum complexes/ Ehrlich solid tumor activity
Solvents
Testicular cancer
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cited_by cdi_FETCH-LOGICAL-c439t-e294ebce0815f786d9d8ca50301f6b0277fb994a3dd0e355f346bd91d39fe5d73
cites cdi_FETCH-LOGICAL-c439t-e294ebce0815f786d9d8ca50301f6b0277fb994a3dd0e355f346bd91d39fe5d73
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container_title Brazilian Journal of Pharmaceutical Sciences
container_volume 53
creator Freire, Rachel Lima Marcelino
Marques, Maria Betânia de Freitas
Souza-Fagundes, Elaine Maria de
Oliveira, Renata Barbosa de
Alves, Ricardo José
description A novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice with Ehrlich solid tumors and it was able to reduce the rate of tumor growth significantly during the first seven days. However, at the end of the experiments, there was no significant difference between the group of animals treated with 3 and the control group. The low solubility of the compound in the assay conditions can explain, at least in part, these results.
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subjects Aqueous solutions
Caustic soda
Cytotoxic activity
Deoxyribonucleic acid
DNA
Ligands
PHARMACOLOGY & PHARMACY
Platinum complexes/ Ehrlich solid tumor activity
Solvents
Testicular cancer
title Synthesis and evaluation of platinum complexes with potential antitumor activity
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