Chidamide-BEAC plus autologous stem cell transplantation in high-risk non-Hodgkin lymphoma: a phase II clinical trial

Chidamide, a novel subtype-selective histone deacetylase inhibitor (HDACi), can directly inhibit tumor cell cycle progression, induce tumor cell apoptosis, and restore the sensitivity of drug-resistant tumor cells to drugs by loosening chromatin and exposing deoxyribonucleic acid (DNA). The protocol...

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Bibliographic Details
Published in:Chinese medical journal 2023-06, Vol.136 (12), p.1491-1493
Main Authors: Xia, Yi, Wang, Li, Ding, Kaiyang, Wu, Jiazhu, Yin, Hua, Hu, Maogui, Shen, Haorui, Liang, Jinhua, Chen, Ruize, Li, Yue, Zhu, Huayuan, Li, Jianyong, Xu, Wei
Format: Article
Language:English
Subjects:
Aminopyridines - therapeutic use
Antineoplastic Combined Chemotherapy Protocols
Cell cycle
Clinical trials
Correspondence
Hematology
Hematopoietic Stem Cell Transplantation
Humans
Kinases
Lymphoma
Lymphoma, Non-Hodgkin - drug therapy
Medical prognosis
Patients
Remission (Medicine)
Stem cell transplantation
T cell receptors
Transplantation, Autologous
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Summary:Chidamide, a novel subtype-selective histone deacetylase inhibitor (HDACi), can directly inhibit tumor cell cycle progression, induce tumor cell apoptosis, and restore the sensitivity of drug-resistant tumor cells to drugs by loosening chromatin and exposing deoxyribonucleic acid (DNA). The protocol of this study was approved by the Institutional Review Board of Jiangsu Province Hospital and Anhui Provincial Cancer Hospital (No. 2017-SR-271). [...]63 patients were included in the per-protocol set (PPS) [Supplementary Figure 1, http://links.lww.com/CM9/B617]. [...]chidamide with anti-programmed cell death protein 1 achieved an objective response rate of 58.3% and a CR rate of 44.4% in treating advanced and relapsed/refractory ENKTL.
ISSN:0366-6999
2542-5641
DOI:10.1097/CM9.0000000000002636