Metronidazole-induced encephalopathy

Metronidazole is a widely used antibacterial and antiprotozoal agent for a number of conditions. Whilst its more common gastrointestinal side effects are well known, neurotoxicity remains under-recognised. Both central and peripheral neurological side effects have been described. This report describ...

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Bibliographic Details
Published in:SA journal of radiology 2021, Vol.25 (1), p.2016-e5
Main Authors: Lala, Vikash G, Bobat, Bilal, Haagensen, Mark, Kathan, Prakash, Mahomed, Adam
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Ataxia
Care and treatment
Case Report
Cerebellar ataxia
Cerebellum
Complications and side effects
Convulsions & seizures
corpus callosum lesions
Cytotoxicity
dentate nucleus lesions
Drug dosages
Edema
Encephalitis
Encephalopathy
Gastrointestinal diseases
Infection
Inflammatory bowel disease
Literature reviews
Magnetic resonance imaging
Metronidazole
metronidazole adverse events
metronidazole-induced cerebellar ataxia
metronidazole-induced encephalopathy
metronidazole-induced neurotoxicity
Neomycin
Neurotoxicity
Peripheral neuropathy
Rifaximin
Side effects
splenium lesions
Systematic review
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Description
Summary:Metronidazole is a widely used antibacterial and antiprotozoal agent for a number of conditions. Whilst its more common gastrointestinal side effects are well known, neurotoxicity remains under-recognised. Both central and peripheral neurological side effects have been described. This report describes a case of radiologically confirmed metronidazole-induced cerebellar ataxia in a cirrhotic patient with a review of the literature. Awareness of this side effect is essential for prompt recognition as early drug withdrawal leads to resolution in the majority of cases.
ISSN:1027-202X
2078-6778
DOI:10.4102/sajr.v25i1.2016