Loading…

Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury

To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients. This prospective observational study was conducted on 71 patients diagnosed with seps...

Full description

Saved in:
Bibliographic Details
Published in:International journal of general medicine 2023-07, Vol.16, p.2933-2941
Main Authors: Nguyen, Van Tri, Nguyen-Phan, Hong Ngoc, Ton, That Ngoc, Hoang, Bui Bao
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73
cites cdi_FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73
container_end_page 2941
container_issue
container_start_page 2933
container_title International journal of general medicine
container_volume 16
creator Nguyen, Van Tri
Nguyen-Phan, Hong Ngoc
Ton, That Ngoc
Hoang, Bui Bao
description To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients. This prospective observational study was conducted on 71 patients diagnosed with sepsis according to Sepsis 3 at the Intensive Care Unit, Hue Central Hospital, Vietnam, from September 2021 to February 2023. Among 71 sepsis patients, there were 38 (53.5%) AKI cases, including 16 (22.5%) cases of stage 1 AKI, 14 (19.7%) cases of stage 2 AKI, 8 (11.3%) cases of stage 3 AKI, 16 (22.5%) cases of renal replacement therapy, 28 (39.4%) cases of septic shock, and 21 (29.6%) cases of mortality within 28 days. The concentrations of lactate and IL-6 in the AKI and mortality groups were statistically significantly greater than those in the non-AKI and survival groups (p < 0.05). The serum sTM concentration was 4.33 ng/mL, the serum sTM level in the AKI group was statistically significantly higher than that in the non-AKI group (sTM [4.71 vs 2.54 ng/mL, p < 0.001]), and the serum sTM level in the mortality group was statistically significantly higher than the survival group (sTM [4.78 vs 3.87 ng/mL, p < 0.001]). The AUC of sTM for predicting AKI was 0.864; the AUCs of sTM, IL-6, SOFA, and APACHE II for predicting mortality were 0.811, 0.671, 0.816, and 0.705, respectively. AKI was a prevalent complication among sepsis patients at the ICU. In the AKI and mortality groups, sTM concentration was statistically significantly higher than that in the non-AKI and survival groups. sTM was the predictor of acute kidney injury and mortality in patients with sepsis.
doi_str_mv 10.2147/IJGM.S417410
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_271d210f2b4b424fbdccb4127c1d3ade</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A760783192</galeid><doaj_id>oai_doaj_org_article_271d210f2b4b424fbdccb4127c1d3ade</doaj_id><sourcerecordid>A760783192</sourcerecordid><originalsourceid>FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73</originalsourceid><addsrcrecordid>eNptksGPEyEUhydG467Vm2dDYmI8OBUGOjCnTbPRtbobN9nVK2HgTUudgQqMpv-91NZNmxgOkMf3vvDIryheEjytCOPvF5-vbqZ3jHBG8KPinBAuSo45e3x0PiuexbjGuK5rQp8WZ5SzGeez6rxw31U_AvIduoMwDuh-FfzQ-sGbsbcOqYgUulHhBwSknEG3AYzVyQeUL29VsuBSRL9tWuX-TbSxnMfotVUJDJrrMQH6Yo2DLVq49Ri2z4snneojvDjsk-Lbxw_3l5_K669Xi8v5dakZb1IJNdFCCVUJykwz46yrBedaVR0WLWgDDFfc4FboxgAFzHKFKc2bjohuZjidFIu913i1lptgBxW20isr_xZ8WEoVktU9yIoTUxHcVS1rWcW61mjdMlJxTQxVWT8pLvauzdgOYHQeOaj-RHp64-xKLv0vSTBlgvI6G94eDMH_HCEmOdiooe-VAz9GmccUNaOsERl9vUeXKr_Nus5npd7hcs5rzAUlTZWp6X-ovAwMVnsHnc31k4Y3Rw0rUH1aRd-PyXoXT8F3e1AHH2OA7mFOguUub3KXN3nIW8ZfHf_NA_wvYPQPY5LQcQ</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2838643498</pqid></control><display><type>article</type><title>Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>Taylor &amp; Francis Open Access</source><source>PubMed Central</source><creator>Nguyen, Van Tri ; Nguyen-Phan, Hong Ngoc ; Ton, That Ngoc ; Hoang, Bui Bao</creator><creatorcontrib>Nguyen, Van Tri ; Nguyen-Phan, Hong Ngoc ; Ton, That Ngoc ; Hoang, Bui Bao</creatorcontrib><description>To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients. This prospective observational study was conducted on 71 patients diagnosed with sepsis according to Sepsis 3 at the Intensive Care Unit, Hue Central Hospital, Vietnam, from September 2021 to February 2023. Among 71 sepsis patients, there were 38 (53.5%) AKI cases, including 16 (22.5%) cases of stage 1 AKI, 14 (19.7%) cases of stage 2 AKI, 8 (11.3%) cases of stage 3 AKI, 16 (22.5%) cases of renal replacement therapy, 28 (39.4%) cases of septic shock, and 21 (29.6%) cases of mortality within 28 days. The concentrations of lactate and IL-6 in the AKI and mortality groups were statistically significantly greater than those in the non-AKI and survival groups (p &lt; 0.05). The serum sTM concentration was 4.33 ng/mL, the serum sTM level in the AKI group was statistically significantly higher than that in the non-AKI group (sTM [4.71 vs 2.54 ng/mL, p &lt; 0.001]), and the serum sTM level in the mortality group was statistically significantly higher than the survival group (sTM [4.78 vs 3.87 ng/mL, p &lt; 0.001]). The AUC of sTM for predicting AKI was 0.864; the AUCs of sTM, IL-6, SOFA, and APACHE II for predicting mortality were 0.811, 0.671, 0.816, and 0.705, respectively. AKI was a prevalent complication among sepsis patients at the ICU. In the AKI and mortality groups, sTM concentration was statistically significantly higher than that in the non-AKI and survival groups. sTM was the predictor of acute kidney injury and mortality in patients with sepsis.</description><identifier>ISSN: 1178-7074</identifier><identifier>EISSN: 1178-7074</identifier><identifier>DOI: 10.2147/IJGM.S417410</identifier><identifier>PMID: 37457752</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>acute kidney injury ; Care and treatment ; Health aspects ; Infection ; Medical research ; Medicine, Experimental ; Mortality ; Original Research ; Prognosis ; sepsis ; Septic shock ; thrombomodulin ; Type 2 diabetes ; Vietnam</subject><ispartof>International journal of general medicine, 2023-07, Vol.16, p.2933-2941</ispartof><rights>2023 Nguyen et al.</rights><rights>COPYRIGHT 2023 Dove Medical Press Limited</rights><rights>2023 Nguyen et al. 2023 Nguyen et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73</citedby><cites>FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348376/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348376/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,37012,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37457752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Van Tri</creatorcontrib><creatorcontrib>Nguyen-Phan, Hong Ngoc</creatorcontrib><creatorcontrib>Ton, That Ngoc</creatorcontrib><creatorcontrib>Hoang, Bui Bao</creatorcontrib><title>Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury</title><title>International journal of general medicine</title><addtitle>Int J Gen Med</addtitle><description>To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients. This prospective observational study was conducted on 71 patients diagnosed with sepsis according to Sepsis 3 at the Intensive Care Unit, Hue Central Hospital, Vietnam, from September 2021 to February 2023. Among 71 sepsis patients, there were 38 (53.5%) AKI cases, including 16 (22.5%) cases of stage 1 AKI, 14 (19.7%) cases of stage 2 AKI, 8 (11.3%) cases of stage 3 AKI, 16 (22.5%) cases of renal replacement therapy, 28 (39.4%) cases of septic shock, and 21 (29.6%) cases of mortality within 28 days. The concentrations of lactate and IL-6 in the AKI and mortality groups were statistically significantly greater than those in the non-AKI and survival groups (p &lt; 0.05). The serum sTM concentration was 4.33 ng/mL, the serum sTM level in the AKI group was statistically significantly higher than that in the non-AKI group (sTM [4.71 vs 2.54 ng/mL, p &lt; 0.001]), and the serum sTM level in the mortality group was statistically significantly higher than the survival group (sTM [4.78 vs 3.87 ng/mL, p &lt; 0.001]). The AUC of sTM for predicting AKI was 0.864; the AUCs of sTM, IL-6, SOFA, and APACHE II for predicting mortality were 0.811, 0.671, 0.816, and 0.705, respectively. AKI was a prevalent complication among sepsis patients at the ICU. In the AKI and mortality groups, sTM concentration was statistically significantly higher than that in the non-AKI and survival groups. sTM was the predictor of acute kidney injury and mortality in patients with sepsis.</description><subject>acute kidney injury</subject><subject>Care and treatment</subject><subject>Health aspects</subject><subject>Infection</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Original Research</subject><subject>Prognosis</subject><subject>sepsis</subject><subject>Septic shock</subject><subject>thrombomodulin</subject><subject>Type 2 diabetes</subject><subject>Vietnam</subject><issn>1178-7074</issn><issn>1178-7074</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptksGPEyEUhydG467Vm2dDYmI8OBUGOjCnTbPRtbobN9nVK2HgTUudgQqMpv-91NZNmxgOkMf3vvDIryheEjytCOPvF5-vbqZ3jHBG8KPinBAuSo45e3x0PiuexbjGuK5rQp8WZ5SzGeez6rxw31U_AvIduoMwDuh-FfzQ-sGbsbcOqYgUulHhBwSknEG3AYzVyQeUL29VsuBSRL9tWuX-TbSxnMfotVUJDJrrMQH6Yo2DLVq49Ri2z4snneojvDjsk-Lbxw_3l5_K669Xi8v5dakZb1IJNdFCCVUJykwz46yrBedaVR0WLWgDDFfc4FboxgAFzHKFKc2bjohuZjidFIu913i1lptgBxW20isr_xZ8WEoVktU9yIoTUxHcVS1rWcW61mjdMlJxTQxVWT8pLvauzdgOYHQeOaj-RHp64-xKLv0vSTBlgvI6G94eDMH_HCEmOdiooe-VAz9GmccUNaOsERl9vUeXKr_Nus5npd7hcs5rzAUlTZWp6X-ovAwMVnsHnc31k4Y3Rw0rUH1aRd-PyXoXT8F3e1AHH2OA7mFOguUub3KXN3nIW8ZfHf_NA_wvYPQPY5LQcQ</recordid><startdate>20230731</startdate><enddate>20230731</enddate><creator>Nguyen, Van Tri</creator><creator>Nguyen-Phan, Hong Ngoc</creator><creator>Ton, That Ngoc</creator><creator>Hoang, Bui Bao</creator><general>Dove Medical Press Limited</general><general>Dove</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230731</creationdate><title>Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury</title><author>Nguyen, Van Tri ; Nguyen-Phan, Hong Ngoc ; Ton, That Ngoc ; Hoang, Bui Bao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>acute kidney injury</topic><topic>Care and treatment</topic><topic>Health aspects</topic><topic>Infection</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mortality</topic><topic>Original Research</topic><topic>Prognosis</topic><topic>sepsis</topic><topic>Septic shock</topic><topic>thrombomodulin</topic><topic>Type 2 diabetes</topic><topic>Vietnam</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Van Tri</creatorcontrib><creatorcontrib>Nguyen-Phan, Hong Ngoc</creatorcontrib><creatorcontrib>Ton, That Ngoc</creatorcontrib><creatorcontrib>Hoang, Bui Bao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of general medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Van Tri</au><au>Nguyen-Phan, Hong Ngoc</au><au>Ton, That Ngoc</au><au>Hoang, Bui Bao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury</atitle><jtitle>International journal of general medicine</jtitle><addtitle>Int J Gen Med</addtitle><date>2023-07-31</date><risdate>2023</risdate><volume>16</volume><spage>2933</spage><epage>2941</epage><pages>2933-2941</pages><issn>1178-7074</issn><eissn>1178-7074</eissn><abstract>To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients. This prospective observational study was conducted on 71 patients diagnosed with sepsis according to Sepsis 3 at the Intensive Care Unit, Hue Central Hospital, Vietnam, from September 2021 to February 2023. Among 71 sepsis patients, there were 38 (53.5%) AKI cases, including 16 (22.5%) cases of stage 1 AKI, 14 (19.7%) cases of stage 2 AKI, 8 (11.3%) cases of stage 3 AKI, 16 (22.5%) cases of renal replacement therapy, 28 (39.4%) cases of septic shock, and 21 (29.6%) cases of mortality within 28 days. The concentrations of lactate and IL-6 in the AKI and mortality groups were statistically significantly greater than those in the non-AKI and survival groups (p &lt; 0.05). The serum sTM concentration was 4.33 ng/mL, the serum sTM level in the AKI group was statistically significantly higher than that in the non-AKI group (sTM [4.71 vs 2.54 ng/mL, p &lt; 0.001]), and the serum sTM level in the mortality group was statistically significantly higher than the survival group (sTM [4.78 vs 3.87 ng/mL, p &lt; 0.001]). The AUC of sTM for predicting AKI was 0.864; the AUCs of sTM, IL-6, SOFA, and APACHE II for predicting mortality were 0.811, 0.671, 0.816, and 0.705, respectively. AKI was a prevalent complication among sepsis patients at the ICU. In the AKI and mortality groups, sTM concentration was statistically significantly higher than that in the non-AKI and survival groups. sTM was the predictor of acute kidney injury and mortality in patients with sepsis.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>37457752</pmid><doi>10.2147/IJGM.S417410</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1178-7074
ispartof International journal of general medicine, 2023-07, Vol.16, p.2933-2941
issn 1178-7074
1178-7074
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_271d210f2b4b424fbdccb4127c1d3ade
source Publicly Available Content Database (Proquest) (PQ_SDU_P3); Taylor & Francis Open Access; PubMed Central
subjects acute kidney injury
Care and treatment
Health aspects
Infection
Medical research
Medicine, Experimental
Mortality
Original Research
Prognosis
sepsis
Septic shock
thrombomodulin
Type 2 diabetes
Vietnam
title Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T13%3A36%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Value%20of%20Serum%20Thrombomodulin%20as%20a%20Marker%20and%20Predictor%20in%20Patients%20with%20Sepsis-Associated%20Acute%20Kidney%20Injury&rft.jtitle=International%20journal%20of%20general%20medicine&rft.au=Nguyen,%20Van%20Tri&rft.date=2023-07-31&rft.volume=16&rft.spage=2933&rft.epage=2941&rft.pages=2933-2941&rft.issn=1178-7074&rft.eissn=1178-7074&rft_id=info:doi/10.2147/IJGM.S417410&rft_dat=%3Cgale_doaj_%3EA760783192%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2838643498&rft_id=info:pmid/37457752&rft_galeid=A760783192&rfr_iscdi=true