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Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury
To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients. This prospective observational study was conducted on 71 patients diagnosed with seps...
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Published in: | International journal of general medicine 2023-07, Vol.16, p.2933-2941 |
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description | To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients.
This prospective observational study was conducted on 71 patients diagnosed with sepsis according to Sepsis 3 at the Intensive Care Unit, Hue Central Hospital, Vietnam, from September 2021 to February 2023.
Among 71 sepsis patients, there were 38 (53.5%) AKI cases, including 16 (22.5%) cases of stage 1 AKI, 14 (19.7%) cases of stage 2 AKI, 8 (11.3%) cases of stage 3 AKI, 16 (22.5%) cases of renal replacement therapy, 28 (39.4%) cases of septic shock, and 21 (29.6%) cases of mortality within 28 days. The concentrations of lactate and IL-6 in the AKI and mortality groups were statistically significantly greater than those in the non-AKI and survival groups (p < 0.05). The serum sTM concentration was 4.33 ng/mL, the serum sTM level in the AKI group was statistically significantly higher than that in the non-AKI group (sTM [4.71 vs 2.54 ng/mL, p < 0.001]), and the serum sTM level in the mortality group was statistically significantly higher than the survival group (sTM [4.78 vs 3.87 ng/mL, p < 0.001]). The AUC of sTM for predicting AKI was 0.864; the AUCs of sTM, IL-6, SOFA, and APACHE II for predicting mortality were 0.811, 0.671, 0.816, and 0.705, respectively.
AKI was a prevalent complication among sepsis patients at the ICU. In the AKI and mortality groups, sTM concentration was statistically significantly higher than that in the non-AKI and survival groups. sTM was the predictor of acute kidney injury and mortality in patients with sepsis. |
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This prospective observational study was conducted on 71 patients diagnosed with sepsis according to Sepsis 3 at the Intensive Care Unit, Hue Central Hospital, Vietnam, from September 2021 to February 2023.
Among 71 sepsis patients, there were 38 (53.5%) AKI cases, including 16 (22.5%) cases of stage 1 AKI, 14 (19.7%) cases of stage 2 AKI, 8 (11.3%) cases of stage 3 AKI, 16 (22.5%) cases of renal replacement therapy, 28 (39.4%) cases of septic shock, and 21 (29.6%) cases of mortality within 28 days. The concentrations of lactate and IL-6 in the AKI and mortality groups were statistically significantly greater than those in the non-AKI and survival groups (p < 0.05). The serum sTM concentration was 4.33 ng/mL, the serum sTM level in the AKI group was statistically significantly higher than that in the non-AKI group (sTM [4.71 vs 2.54 ng/mL, p < 0.001]), and the serum sTM level in the mortality group was statistically significantly higher than the survival group (sTM [4.78 vs 3.87 ng/mL, p < 0.001]). The AUC of sTM for predicting AKI was 0.864; the AUCs of sTM, IL-6, SOFA, and APACHE II for predicting mortality were 0.811, 0.671, 0.816, and 0.705, respectively.
AKI was a prevalent complication among sepsis patients at the ICU. In the AKI and mortality groups, sTM concentration was statistically significantly higher than that in the non-AKI and survival groups. sTM was the predictor of acute kidney injury and mortality in patients with sepsis.</description><identifier>ISSN: 1178-7074</identifier><identifier>EISSN: 1178-7074</identifier><identifier>DOI: 10.2147/IJGM.S417410</identifier><identifier>PMID: 37457752</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>acute kidney injury ; Care and treatment ; Health aspects ; Infection ; Medical research ; Medicine, Experimental ; Mortality ; Original Research ; Prognosis ; sepsis ; Septic shock ; thrombomodulin ; Type 2 diabetes ; Vietnam</subject><ispartof>International journal of general medicine, 2023-07, Vol.16, p.2933-2941</ispartof><rights>2023 Nguyen et al.</rights><rights>COPYRIGHT 2023 Dove Medical Press Limited</rights><rights>2023 Nguyen et al. 2023 Nguyen et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73</citedby><cites>FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348376/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10348376/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,37012,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37457752$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Van Tri</creatorcontrib><creatorcontrib>Nguyen-Phan, Hong Ngoc</creatorcontrib><creatorcontrib>Ton, That Ngoc</creatorcontrib><creatorcontrib>Hoang, Bui Bao</creatorcontrib><title>Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury</title><title>International journal of general medicine</title><addtitle>Int J Gen Med</addtitle><description>To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients.
This prospective observational study was conducted on 71 patients diagnosed with sepsis according to Sepsis 3 at the Intensive Care Unit, Hue Central Hospital, Vietnam, from September 2021 to February 2023.
Among 71 sepsis patients, there were 38 (53.5%) AKI cases, including 16 (22.5%) cases of stage 1 AKI, 14 (19.7%) cases of stage 2 AKI, 8 (11.3%) cases of stage 3 AKI, 16 (22.5%) cases of renal replacement therapy, 28 (39.4%) cases of septic shock, and 21 (29.6%) cases of mortality within 28 days. The concentrations of lactate and IL-6 in the AKI and mortality groups were statistically significantly greater than those in the non-AKI and survival groups (p < 0.05). The serum sTM concentration was 4.33 ng/mL, the serum sTM level in the AKI group was statistically significantly higher than that in the non-AKI group (sTM [4.71 vs 2.54 ng/mL, p < 0.001]), and the serum sTM level in the mortality group was statistically significantly higher than the survival group (sTM [4.78 vs 3.87 ng/mL, p < 0.001]). The AUC of sTM for predicting AKI was 0.864; the AUCs of sTM, IL-6, SOFA, and APACHE II for predicting mortality were 0.811, 0.671, 0.816, and 0.705, respectively.
AKI was a prevalent complication among sepsis patients at the ICU. In the AKI and mortality groups, sTM concentration was statistically significantly higher than that in the non-AKI and survival groups. sTM was the predictor of acute kidney injury and mortality in patients with sepsis.</description><subject>acute kidney injury</subject><subject>Care and treatment</subject><subject>Health aspects</subject><subject>Infection</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Mortality</subject><subject>Original Research</subject><subject>Prognosis</subject><subject>sepsis</subject><subject>Septic shock</subject><subject>thrombomodulin</subject><subject>Type 2 diabetes</subject><subject>Vietnam</subject><issn>1178-7074</issn><issn>1178-7074</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptksGPEyEUhydG467Vm2dDYmI8OBUGOjCnTbPRtbobN9nVK2HgTUudgQqMpv-91NZNmxgOkMf3vvDIryheEjytCOPvF5-vbqZ3jHBG8KPinBAuSo45e3x0PiuexbjGuK5rQp8WZ5SzGeez6rxw31U_AvIduoMwDuh-FfzQ-sGbsbcOqYgUulHhBwSknEG3AYzVyQeUL29VsuBSRL9tWuX-TbSxnMfotVUJDJrrMQH6Yo2DLVq49Ri2z4snneojvDjsk-Lbxw_3l5_K669Xi8v5dakZb1IJNdFCCVUJykwz46yrBedaVR0WLWgDDFfc4FboxgAFzHKFKc2bjohuZjidFIu913i1lptgBxW20isr_xZ8WEoVktU9yIoTUxHcVS1rWcW61mjdMlJxTQxVWT8pLvauzdgOYHQeOaj-RHp64-xKLv0vSTBlgvI6G94eDMH_HCEmOdiooe-VAz9GmccUNaOsERl9vUeXKr_Nus5npd7hcs5rzAUlTZWp6X-ovAwMVnsHnc31k4Y3Rw0rUH1aRd-PyXoXT8F3e1AHH2OA7mFOguUub3KXN3nIW8ZfHf_NA_wvYPQPY5LQcQ</recordid><startdate>20230731</startdate><enddate>20230731</enddate><creator>Nguyen, Van Tri</creator><creator>Nguyen-Phan, Hong Ngoc</creator><creator>Ton, That Ngoc</creator><creator>Hoang, Bui Bao</creator><general>Dove Medical Press Limited</general><general>Dove</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20230731</creationdate><title>Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury</title><author>Nguyen, Van Tri ; Nguyen-Phan, Hong Ngoc ; Ton, That Ngoc ; Hoang, Bui Bao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-e61c8a8a2834d9574f6877ca2f08becde4027d0b8c9de3e04de44ac79f18f5d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>acute kidney injury</topic><topic>Care and treatment</topic><topic>Health aspects</topic><topic>Infection</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Mortality</topic><topic>Original Research</topic><topic>Prognosis</topic><topic>sepsis</topic><topic>Septic shock</topic><topic>thrombomodulin</topic><topic>Type 2 diabetes</topic><topic>Vietnam</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Van Tri</creatorcontrib><creatorcontrib>Nguyen-Phan, Hong Ngoc</creatorcontrib><creatorcontrib>Ton, That Ngoc</creatorcontrib><creatorcontrib>Hoang, Bui Bao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of general medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Van Tri</au><au>Nguyen-Phan, Hong Ngoc</au><au>Ton, That Ngoc</au><au>Hoang, Bui Bao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury</atitle><jtitle>International journal of general medicine</jtitle><addtitle>Int J Gen Med</addtitle><date>2023-07-31</date><risdate>2023</risdate><volume>16</volume><spage>2933</spage><epage>2941</epage><pages>2933-2941</pages><issn>1178-7074</issn><eissn>1178-7074</eissn><abstract>To investigate the serum soluble thrombomodulin (sTM) concentration in patients with sepsis-associated acute kidney injury (AKI) and to determine the value of sTM in predicting AKI and mortality in sepsis patients.
This prospective observational study was conducted on 71 patients diagnosed with sepsis according to Sepsis 3 at the Intensive Care Unit, Hue Central Hospital, Vietnam, from September 2021 to February 2023.
Among 71 sepsis patients, there were 38 (53.5%) AKI cases, including 16 (22.5%) cases of stage 1 AKI, 14 (19.7%) cases of stage 2 AKI, 8 (11.3%) cases of stage 3 AKI, 16 (22.5%) cases of renal replacement therapy, 28 (39.4%) cases of septic shock, and 21 (29.6%) cases of mortality within 28 days. The concentrations of lactate and IL-6 in the AKI and mortality groups were statistically significantly greater than those in the non-AKI and survival groups (p < 0.05). The serum sTM concentration was 4.33 ng/mL, the serum sTM level in the AKI group was statistically significantly higher than that in the non-AKI group (sTM [4.71 vs 2.54 ng/mL, p < 0.001]), and the serum sTM level in the mortality group was statistically significantly higher than the survival group (sTM [4.78 vs 3.87 ng/mL, p < 0.001]). The AUC of sTM for predicting AKI was 0.864; the AUCs of sTM, IL-6, SOFA, and APACHE II for predicting mortality were 0.811, 0.671, 0.816, and 0.705, respectively.
AKI was a prevalent complication among sepsis patients at the ICU. In the AKI and mortality groups, sTM concentration was statistically significantly higher than that in the non-AKI and survival groups. sTM was the predictor of acute kidney injury and mortality in patients with sepsis.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>37457752</pmid><doi>10.2147/IJGM.S417410</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | acute kidney injury Care and treatment Health aspects Infection Medical research Medicine, Experimental Mortality Original Research Prognosis sepsis Septic shock thrombomodulin Type 2 diabetes Vietnam |
title | Value of Serum Thrombomodulin as a Marker and Predictor in Patients with Sepsis-Associated Acute Kidney Injury |
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