Antarctic Marine Bacteria as a Source of Anti-Biofilm Molecules to Combat ESKAPE Pathogens

The ESKAPE pathogens, including bacteria such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species, pose a global health threat due to their ability to resist antimicrobial drugs and evade the immune system....

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-10, Vol.12 (10), p.1556
Main Authors: Artini, Marco, Papa, Rosanna, Vrenna, Gianluca, Trecca, Marika, Paris, Irene, D’Angelo, Caterina, Tutino, Maria Luisa, Parrilli, Ermenegilda, Selan, Laura
Format: Article
Language:English
Subjects:
Acinetobacter baumannii
Antibiotics
Antimicrobial activity
Antimicrobial agents
Bacteria
Bacterial pneumonia
Biofilms
Drug resistance
Drug resistance in microorganisms
Enterobacter sp
Enterococcus faecium
Global health
Health aspects
Health risks
Hospitals
Imipenem
Immune system
Immunosuppressive agents
Intensive care units
Klebsiella
Klebsiella pneumoniae
Microorganisms
Multidrug resistance
Nosocomial infection
Nosocomial infections
Pathogenic microorganisms
Pathogens
Pneumonia
Prevention
Pseudomonas aeruginosa
Public health
Quality control
Staphylococcus aureus
Staphylococcus infections
Tetracycline
Tetracyclines
Virulence
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Summary:The ESKAPE pathogens, including bacteria such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species, pose a global health threat due to their ability to resist antimicrobial drugs and evade the immune system. These pathogens are responsible for hospital-acquired infections, especially in intensive care units, and contribute to the growing problem of multi-drug resistance. In this study, researchers focused on exploring the potential of Antarctic marine bacteria as a source of anti-biofilm molecules to combat ESKAPE pathogens. Four Antarctic bacterial strains were selected, and their cell-free supernatants were tested against 60 clinical ESKAPE isolates. The results showed that the supernatants did not exhibit antimicrobial activity but effectively prevented biofilm formation and dispersed mature biofilms. This research highlights the promising potential of Antarctic bacteria in producing compounds that can counteract biofilms formed by clinically significant bacterial species. These findings contribute to the development of new strategies for preventing and controlling infections caused by ESKAPE pathogens.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12101556