Interleukin-23 levels in umbilical cord blood are associated with neurodevelopmental trajectories in infancy

Our previous study, which aimed to understand the early neurodevelopmental trajectories of children with and without neurodevelopmental disorders, identified five classes of early neurodevelopmental trajectories, categorized as high normal, normal, low normal, delayed, and markedly delayed. This inv...

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Bibliographic Details
Published in:PloS one 2024-04, Vol.19 (4), p.e0301982-e0301982
Main Authors: Asaka, Machiko K, Nishimura, Tomoko, Kuwabara, Hitoshi, Itoh, Hiroaki, Takahashi, Nagahide, Tsuchiya, Kenji J
Format: Article
Language:English
Subjects:
Analysis
Biology and Life Sciences
Care and treatment
Child
Child development deviations
Child, Preschool
Cytokines
Developmental disabilities
Diagnosis
Fetal Blood
Genetic aspects
Health aspects
Humans
Infant
Infant, Newborn
Infants (Newborn)
Interleukin-23
Interleukins
Medical colleges
Medicine and Health Sciences
Neurodevelopmental Disorders
People and Places
Single nucleotide polymorphisms
Umbilical Cord
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Summary:Our previous study, which aimed to understand the early neurodevelopmental trajectories of children with and without neurodevelopmental disorders, identified five classes of early neurodevelopmental trajectories, categorized as high normal, normal, low normal, delayed, and markedly delayed. This investigation involved measurement using the Mullen Scale of Early Learning in a representative sample of Japanese infants followed up from the age of 0 to 2 years (Nishimura et al., 2016). In the present study, we investigated the potential association between cytokine concentrations in umbilical cord serum with any of the five classes of neurodevelopmental trajectories previously assigned, as follows: high normal (N = 85, 13.0%), normal (N = 322, 49.1%), low normal (N = 137, 20.9%), delayed (N = 87, 13.3%), and markedly delayed (N = 25, 3.8%) in infancy. Decreased interleukin (IL)-23 levels in the cord blood were associated with the markedly delayed class, independent of potential confounders (odds ratio, 0.44; 95%confidence interval: 0.26-0.73). Furthermore, IL-23 levels decreased as the developmental trajectory became more delayed, demonstrating that IL-23 plays an important role in development, and is useful for predicting the developmental trajectory at birth.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0301982