Identification and Analytical Characterization of a Novel Synthetic Cannabinoid-Type Substance in Herbal Material in Europe

The rapid diffusion of new psychoactive substances (NPS) presents unprecedented challenges to both customs authorities and analytical laboratories involved in their detection and characterization. In this study an analytical approach to the identification and structural elucidation of a novel synthe...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2021-02, Vol.26 (4), p.793
Main Authors: Tsochatzis, Emmanouil D, Alberto Lopes, Joao, Holland, Margaret V, Reniero, Fabiano, Palmieri, Giovanni, Guillou, Claude
Format: Article
Language:English
Subjects:
2F-QMPSB
Acids
Benzoic acid
Cannabinoid receptors
Cannabinoids - analysis
Cannabinoids - chemical synthesis
Cannabinoids - chemistry
cheminformatics
Chromatography
Customs
Europe
Gas chromatography
GC-MS
HR-MS/MS
Identification
Illicit Drugs - analysis
Illicit Drugs - chemical synthesis
Illicit Drugs - chemistry
Informatics
Laboratories
Mass spectrometry
Mass spectroscopy
NMR
Nuclear magnetic resonance
Nuclear Magnetic Resonance, Biomolecular
Scientific imaging
Seizing
Spectroscopy
synthetic cannabinoids
Tandem Mass Spectrometry
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Summary:The rapid diffusion of new psychoactive substances (NPS) presents unprecedented challenges to both customs authorities and analytical laboratories involved in their detection and characterization. In this study an analytical approach to the identification and structural elucidation of a novel synthetic cannabimimetic, quinolin-8-yl-3-[(4,4-difluoropiperidin-1-yl) sulfonyl]-4-methylbenzoate (2F-QMPSB), detected in seized herbal material, is detailed. An acid precursor 4-methyl-3-(4,4-difluoro-1-piperidinylsulfonyl) benzoic acid (2F-MPSBA), has also been identified in the same seized material. After extraction from the herbal material the synthetic cannabimimetic, also referred to as synthetic cannabinoid receptor agonists or "synthetic cannabinoids", was characterized using gas chromatography-mass spectrometry (GC-MS), H, C, F and N nuclear magnetic resonance (NMR) and high-resolution tandem mass spectrometry (HR-MS/MS) combined with chromatographic separation. A cheminformatics platform was used to manage and interpret the analytical data from these techniques.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules26040793