Tuberculosis reinfection in a pregnant cystic fibrosis patient

Abstract Cystic Fibrosis (CF) is a multisystem disease predominantly affecting the airways and predisposing patients to recurrent infections with various multidrug resistant organisms. Mycobacterium tuberculosis (MTB) infection is rarely seen, but considered a potential pathogen in CF patients. We r...

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Bibliographic Details
Published in:Respiratory medicine case reports 2015-01, Vol.16 (C), p.57-59
Main Authors: Marco, Asween, Montales, Maria Theresa, Mittadodla, Penchala, Mukasa, Leonard, Bhaskar, Nutan, Bates, Joseph, Patil, Naveen
Format: Article
Language:English
Subjects:
AFB
Case Report
Cystic fibrosis
GeneXpert MTB/RIF assay
Genotyping
Internal Medicine
Mycobacterium tuberculosis
Pulmonary/Respiratory
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Summary:Abstract Cystic Fibrosis (CF) is a multisystem disease predominantly affecting the airways and predisposing patients to recurrent infections with various multidrug resistant organisms. Mycobacterium tuberculosis (MTB) infection is rarely seen, but considered a potential pathogen in CF patients. We report a 26 year old pregnant CF patient on Ivacaftor who was admitted with symptoms suggestive of tuberculosis. Three years prior to the current admission, she had completed four drug anti- MTB therapy for pulmonary tuberculosis and was considered cured as her sputum cultures after six months of treatment were negative. Genotype analysis revealed the current MTB strain to be different from the strain causing the previous infection. After receiving first line anti-tuberculous regimen for nine months, the patient's condition markedly improved culminating in an uneventful pregnancy and delivery. To our knowledge, this is the only reported case of reinfection tuberculosis in a CF patient.
ISSN:2213-0071
2213-0071
DOI:10.1016/j.rmcr.2015.04.002