Gliomatosis cerebri mimicking diffuse demyelinating disease: Case Report

Gliomatosis Cerebri (GC) is a rareand rapidly progressive pattern of growth of diffusely infiltrating gliomas with limited treatment options. Imaging findings are usually nonspecific and can mimic other neurologic disorders, including demyelination, encephalitis, and multicentric/multifocal glioma....

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Bibliographic Details
Published in:Radiology case reports 2020-09, Vol.15 (9), p.1683-1688
Main Authors: Mingomataj, Erli, Soleiman, Aron, Sajan, Abin, Velayudhan, Vinodkumar
Format: Article
Language:English
Subjects:
Diffuse glioma
Gliomatosis cerebri
Neuroradiology
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Summary:Gliomatosis Cerebri (GC) is a rareand rapidly progressive pattern of growth of diffusely infiltrating gliomas with limited treatment options. Imaging findings are usually nonspecific and can mimic other neurologic disorders, including demyelination, encephalitis, and multicentric/multifocal glioma. In this report, we describe a case of a 53-year-old female who presented with left hemiparesis, global headache, and gait ataxia with imaging features initially thought to represent demyelinating disease. A combination of conventional and advanced imaging findings with brain biopsy was utilized to make the diagnosis of GC. In patients with widespread abnormalities on brain imaging, GC should strongly be considered when cortical expansion, involvement of the septum pellucidum and elevated myoinositol levels are observed and the clinical and laboratory findings are atypical for demyelination or infection. Considering GC in such cases can facilitate early biopsy with prompt diagnosis and avoid delay in appropriate treatment.
ISSN:1930-0433
1930-0433
DOI:10.1016/j.radcr.2020.06.043