Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?

Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2021-10, Vol.22 (21), p.11579
Main Authors: Rapacka-Zdonczyk, Aleksandra, Wozniak, Agata, Kruszewska, Beata, Waleron, Krzysztof, Grinholc, Mariusz
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
antimicrobial blue light
Bacteria
Deficient mutant
Drug resistance
Drug Resistance, Bacterial - genetics
E coli
Efficiency
Escherichia coli
Escherichia coli Proteins - genetics
Global health
Gram-negative bacteria
Gram-Negative Bacteria - genetics
Gram-positive bacteria
Klebsiella
Klebsiella pneumoniae
Light
Multidrug resistant organisms
Nosocomial infections
Pathogens
Phototherapy - methods
Pseudomonas aeruginosa
RecA protein
resistance
tolerance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in , , and and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving K-12 -, , , and -deficient mutants revealed some possible mechanisms for aBL tolerance development.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222111579