Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential

Infertility, a couple's inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional therapies. The present study aimed to in...

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Bibliographic Details
Published in:Antioxidants 2020-10, Vol.9 (10), p.957
Main Authors: Noh, Seungjin, Go, Ara, Kim, Da Bin, Park, Minjeong, Jeon, Hee Won, Kim, Bonglee
Format: Article
Language:English
Subjects:
Acute toxicity
anti-inflammation
Antioxidants
Antioxidants (Nutrients)
Care and treatment
Cholesterol
Clinical trials
Endometrium
Free radicals
Health aspects
Herbal medicine
Hormones
Infertility
Insulin
Insulin resistance
Natural products
Oxidative stress
plant extract
Polycystic ovary syndrome
Reactive oxygen species
Review
Traditional Chinese medicine
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Summary:Infertility, a couple's inability to conceive after one year of unprotected regular intercourse, is an important issue in the world. The use of natural products in the treatment of infertility has been considered as a possible alternative to conventional therapies. The present study aimed to investigate the effects and the mechanisms of various natural products on infertility. We collected articles regarding infertility and natural products using the research databases PubMed and Google Scholar. Several natural products possess antioxidant properties and androgenic activities on productive factors and hormones. Antioxidants are the first defense barrier against free radicals produced by oxidative stress (OS). They remove reactive oxygen stress (ROS), reducing insulin resistance, total cholesterol, fat accumulation, and cancer growth. Moreover, various natural products increase endometrial receptivity and fertility ability showing androgenic activities on productive factors and hormones. For example, powder and Astragalus mongholicus extract showed anti-infertility efficacies in males and females, respectively. On the other hand, adverse effects and acute toxicity of natural products were also reported. Tripterygium glycoside decreased fertility ability both in males and females. Results indicate that management of infertility with natural products could be beneficial with further clinical trials to evaluate the safety and effect.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox9100957