Advances in Tumour-Infiltrating Lymphocytes for Triple-Negative Breast Cancer Management

Triple negative breast cancer (TNBC) is a subtype of breast cancer which does not express or expresses a minimum amount of estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor 2 (HER2) protein. TNBCs include a heterogenic group of cancers that are aggressiv...

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Bibliographic Details
Published in:Breast cancer targets and therapy 2023-11, Vol.15, p.773-783
Main Authors: Gorenšek, Rok, Kresnik, Martin, Takač, Iztok, Rojko, Tomaž, Sobočan, Monika
Format: Article
Language:English
Subjects:
B cells
Breast cancer
Development and progression
dysfunction/exhaustion
Estrogen
Health aspects
immunometabo-lism
Immunotherapy
Medical research
Medicine, Experimental
microenvironment
Progesterone
Prognosis
Review
tumor infiltrating lymphocytes
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Summary:Triple negative breast cancer (TNBC) is a subtype of breast cancer which does not express or expresses a minimum amount of estrogen receptors (ER), progesterone receptors (PR) and human epidermal growth factor receptor 2 (HER2) protein. TNBCs include a heterogenic group of cancers that are aggressive, grow rapidly and are associated with poor prognosis and overall survival, mainly attributed to a lack of effective therapeutic targets. For a long time, a major issue with predicting the outcome and prognosis of TNBCs was the lack of an accurate biomarker, a molecule that helps us objectively assess a patient's health status. In recent times, defining the presence of tumor-infiltrating lymphocytes (TIL) is becoming an indispensable method of determining a patient's prognosis. TILs are found in tumor tissue and the surrounding stroma and carry a prognostic value. Furthermore, they are known to improve the effect of systemic therapy. With the rise of immunotherapy, the role of TIL in this newer therapeutic option is a topic of increased importance. The goal behind this research article is a comprehensive review of the current literature on the importance of tumor-infiltrating lymphocytes in the prognosis of TNBC. Keywords: tumor-infiltrating lymphocytes, immunotherapy, prognosis, dysfunction/exhaustion, microenvironment, immunometabolism
ISSN:1179-1314
1179-1314
DOI:10.2147/BCTT.S399157