The regional neuronal activity in left posterior middle temporal gyrus is correlated with the severity of chronic aphasia

Aphasia is one of the most disabling cognitive deficits affecting >2 million people in the USA. The neuroimaging characteristics of chronic aphasic patients (>6 months post onset) remain largely unknown. The objective of this study was to investigate the regional signal changes of spontaneous...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2017-01, Vol.13, p.1937-1945
Main Authors: Li, Jianlin, Du, Dunren, Gao, Wei, Sun, Xichun, Xie, Haizhu, Zhang, Gang, Li, Jian, Li, Honglun, Li, Kefeng
Format: Article
Language:English
Subjects:
Alzheimer's disease
amplitude of low-frequency fluctuation (ALFF)
Aphasia
Brain research
Chronic aphasia
Development and progression
fMRI
Genetic aspects
Hospitals
Language
left posterior middle temporal gyrus
Neurons
NMR
Nuclear magnetic resonance
Original Research
Physiological aspects
Semantics
Stroke
Studies
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Summary:Aphasia is one of the most disabling cognitive deficits affecting >2 million people in the USA. The neuroimaging characteristics of chronic aphasic patients (>6 months post onset) remain largely unknown. The objective of this study was to investigate the regional signal changes of spontaneous neuronal activity of brain and the inter-regional connectivity in chronic aphasia. Resting-state blood oxygenation level-dependent functional magnetic resonance imaging (fMRI) was used to obtain fMRI data from 17 chronic aphasic patients and 20 healthy control subjects in a Siemens Verio 3.0T MR Scanner. The amplitude of low-frequency fluctuation (ALFF) was determined, which directly reflects the regional neuronal activity. The functional connectivity (FC) of fMRI was assessed using a seed voxel linear correlation approach. The severity of aphasia was evaluated by aphasia quotient (AQ) scores obtained from Western Aphasia Battery test. Compared with normal subjects, aphasic patients showed decreased ALFF values in the regions of left posterior middle temporal gyrus (PMTG), left medial prefrontal gyrus, and right cerebellum. The ALFF values in left PMTG showed strong positive correlation with the AQ score (coefficient =0.79,
ISSN:1176-6328
1178-2021
1178-2021
DOI:10.2147/NDT.S140091