Ultra-High-Field Magnetic Resonance Spectroscopy in Psychiatry

The advantages of ultra-high-field (UHF ≥ 7T) MR have been demonstrated in a variety of MR acquisition modalities. Magnetic resonance spectroscopy (MRS) can particularly benefit from substantial gains in signal-to-noise ratio (SNR) and spectral resolution at UHF, enabling the quantification of numer...

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Bibliographic Details
Published in:Frontiers in psychiatry 2017-07, Vol.8, p.123-123
Main Authors: Godlewska, Beata R, Clare, Stuart, Cowen, Philip J, Emir, Uzay E
Format: Article
Language:English
Subjects:
magnetic resonance spectroscopic imaging
magnetic resonance spectroscopy
neurochemicals
psychiatric disorders
Psychiatry
ultra-high-field
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Summary:The advantages of ultra-high-field (UHF ≥ 7T) MR have been demonstrated in a variety of MR acquisition modalities. Magnetic resonance spectroscopy (MRS) can particularly benefit from substantial gains in signal-to-noise ratio (SNR) and spectral resolution at UHF, enabling the quantification of numerous metabolites, including glutamate, glutamine, glutathione, and γ-aminobutyric acid that are relevant to psychiatric disorders. The aim of this review is to give an overview about the advantages and advances of UHF MRS and its application to psychiatric disorders. In order to provide a practical guide for potential applications of MRS at UHF, a literature review is given, surveying advantages and disadvantages of MRS at UHF. Key concepts, emerging technologies, practical considerations, and applications of UHF MRS are provided. Second, the strength of UHF MRS is demonstrated using some examples of its application in psychiatric disorders.
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2017.00123