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Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways
Pall. exhibits antioxidant, antiviral, and anti-inflammatory properties; however, its pharmacological mechanism in allergy is yet to be understood. This study confirmed the effects of Pall. leaf extract (RLE) on allergy as a new promising material. To evaluate the therapeutic potential of RLE agains...
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| Published in: | Plants (Basel) 2023-04, Vol.12 (7), p.1572 |
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| container_start_page | 1572 |
| container_title | Plants (Basel) |
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| creator | Lim, Seojun Oh, Sarang Nguyen, Quynh T N Kim, Myeongju Zheng, Shengdao Fang, Minzhe Yi, Tae-Hoo |
| description | Pall. exhibits antioxidant, antiviral, and anti-inflammatory properties; however, its pharmacological mechanism in allergy is yet to be understood. This study confirmed the effects of
Pall. leaf extract (RLE) on allergy as a new promising material. To evaluate the therapeutic potential of RLE against allergy, we investigated the effects of RLE on the regulatory β-hexosaminidase, histamine, histidine decarboxylase (HDC), Ca
influx, nitric oxide (NO), and cytokines induced by lipopolysaccharide (LPS) and DNP-IgE/BSA in Raw 264.7 and RBL-2H3 cells. Furthermore, we examined the effects of RLE on the signaling pathways of mitogen-activated protein kinase (MAPK) and Ca
pathways. After stimulating Raw 264.7 cells with LPS, RLE reduced the release of inflammatory mediators, such as NO, cyclooxygenase (COX)-2, inducible nitric oxygen synthase (iNOS), interleukin (IL)-1β, -6, and tumor necrosis factor (TNF)-α. Also, RLE reduced the β-hexosaminidase, histamine, HDC, Ca
influx, Ca
pathways, and phosphorylation of MAPK in DNP-IgE/BSA-stimulated RBL-2H3 cells. Our studies indicated that RLE is a valuable ingredient for treating allergic diseases by regulating cytokine release from macrophages and mast cell degranulation. Consequently, these results suggested that RLE may serve as a possible alternative promising material for treating allergies. |
| doi_str_mv | 10.3390/plants12071572 |
| format | article |
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Pall. leaf extract (RLE) on allergy as a new promising material. To evaluate the therapeutic potential of RLE against allergy, we investigated the effects of RLE on the regulatory β-hexosaminidase, histamine, histidine decarboxylase (HDC), Ca
influx, nitric oxide (NO), and cytokines induced by lipopolysaccharide (LPS) and DNP-IgE/BSA in Raw 264.7 and RBL-2H3 cells. Furthermore, we examined the effects of RLE on the signaling pathways of mitogen-activated protein kinase (MAPK) and Ca
pathways. After stimulating Raw 264.7 cells with LPS, RLE reduced the release of inflammatory mediators, such as NO, cyclooxygenase (COX)-2, inducible nitric oxygen synthase (iNOS), interleukin (IL)-1β, -6, and tumor necrosis factor (TNF)-α. Also, RLE reduced the β-hexosaminidase, histamine, HDC, Ca
influx, Ca
pathways, and phosphorylation of MAPK in DNP-IgE/BSA-stimulated RBL-2H3 cells. Our studies indicated that RLE is a valuable ingredient for treating allergic diseases by regulating cytokine release from macrophages and mast cell degranulation. Consequently, these results suggested that RLE may serve as a possible alternative promising material for treating allergies.</description><identifier>ISSN: 2223-7747</identifier><identifier>EISSN: 2223-7747</identifier><identifier>DOI: 10.3390/plants12071572</identifier><identifier>PMID: 37050198</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Allergic diseases ; Allergies ; allergy ; Anaphylaxis ; Anti-inflammatory agents ; Antiviral activity ; Asthma ; Ca2+ influx ; Calcium influx ; Calcium ions ; Calcium oxide ; Calcium signalling ; Cyclooxygenase-2 ; Cytokines ; Degranulation ; Dermatitis ; Gene expression ; Histamine ; Histidine ; Histidine decarboxylase ; histidine decarboxylase (HDC) ; Hypersensitivity ; Immunoglobulin E ; Inflammation ; Interleukins ; Kinases ; Lipopolysaccharides ; Macrophages ; MAP kinase ; Nitric oxide ; Nitric-oxide synthase ; Pathogenesis ; Phosphorylation ; Plant extracts ; Prostaglandin endoperoxide synthase ; Protein expression ; Proteins ; Rhinitis ; Rosa davurica ; Signal transduction ; Signaling ; Transcription factors ; β-hexosaminidase</subject><ispartof>Plants (Basel), 2023-04, Vol.12 (7), p.1572</ispartof><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-4ade953a855479e971c07cec9f746db847143884f04bc22b83177311bd69d3293</citedby><cites>FETCH-LOGICAL-c485t-4ade953a855479e971c07cec9f746db847143884f04bc22b83177311bd69d3293</cites><orcidid>0000-0003-4802-1014 ; 0000-0002-7818-0529 ; 0000-0001-9369-6542</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2800035695/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2800035695?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37050198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lim, Seojun</creatorcontrib><creatorcontrib>Oh, Sarang</creatorcontrib><creatorcontrib>Nguyen, Quynh T N</creatorcontrib><creatorcontrib>Kim, Myeongju</creatorcontrib><creatorcontrib>Zheng, Shengdao</creatorcontrib><creatorcontrib>Fang, Minzhe</creatorcontrib><creatorcontrib>Yi, Tae-Hoo</creatorcontrib><title>Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways</title><title>Plants (Basel)</title><addtitle>Plants (Basel)</addtitle><description>Pall. exhibits antioxidant, antiviral, and anti-inflammatory properties; however, its pharmacological mechanism in allergy is yet to be understood. This study confirmed the effects of
Pall. leaf extract (RLE) on allergy as a new promising material. To evaluate the therapeutic potential of RLE against allergy, we investigated the effects of RLE on the regulatory β-hexosaminidase, histamine, histidine decarboxylase (HDC), Ca
influx, nitric oxide (NO), and cytokines induced by lipopolysaccharide (LPS) and DNP-IgE/BSA in Raw 264.7 and RBL-2H3 cells. Furthermore, we examined the effects of RLE on the signaling pathways of mitogen-activated protein kinase (MAPK) and Ca
pathways. After stimulating Raw 264.7 cells with LPS, RLE reduced the release of inflammatory mediators, such as NO, cyclooxygenase (COX)-2, inducible nitric oxygen synthase (iNOS), interleukin (IL)-1β, -6, and tumor necrosis factor (TNF)-α. Also, RLE reduced the β-hexosaminidase, histamine, HDC, Ca
influx, Ca
pathways, and phosphorylation of MAPK in DNP-IgE/BSA-stimulated RBL-2H3 cells. Our studies indicated that RLE is a valuable ingredient for treating allergic diseases by regulating cytokine release from macrophages and mast cell degranulation. Consequently, these results suggested that RLE may serve as a possible alternative promising material for treating allergies.</description><subject>Allergic diseases</subject><subject>Allergies</subject><subject>allergy</subject><subject>Anaphylaxis</subject><subject>Anti-inflammatory agents</subject><subject>Antiviral activity</subject><subject>Asthma</subject><subject>Ca2+ influx</subject><subject>Calcium influx</subject><subject>Calcium ions</subject><subject>Calcium oxide</subject><subject>Calcium signalling</subject><subject>Cyclooxygenase-2</subject><subject>Cytokines</subject><subject>Degranulation</subject><subject>Dermatitis</subject><subject>Gene expression</subject><subject>Histamine</subject><subject>Histidine</subject><subject>Histidine decarboxylase</subject><subject>histidine decarboxylase (HDC)</subject><subject>Hypersensitivity</subject><subject>Immunoglobulin E</subject><subject>Inflammation</subject><subject>Interleukins</subject><subject>Kinases</subject><subject>Lipopolysaccharides</subject><subject>Macrophages</subject><subject>MAP kinase</subject><subject>Nitric oxide</subject><subject>Nitric-oxide synthase</subject><subject>Pathogenesis</subject><subject>Phosphorylation</subject><subject>Plant extracts</subject><subject>Prostaglandin endoperoxide synthase</subject><subject>Protein expression</subject><subject>Proteins</subject><subject>Rhinitis</subject><subject>Rosa davurica</subject><subject>Signal transduction</subject><subject>Signaling</subject><subject>Transcription factors</subject><subject>β-hexosaminidase</subject><issn>2223-7747</issn><issn>2223-7747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkk1vEzEQhi0EolXolSNaiQuXFH_t2ntCVQQ0UhGowNkaf-zGkbMOtrco_x6XlKrBGsmW551H9ryD0GuCLxnr8ft9gKlkQrEgraDP0DmllC2F4OL5k_MZush5i-uSNUj3Ep0xgVtMenmO4DZmaCzczckbaNbTxmtfnG2uQnBp9Kb54qyHElNu9KG5deMcoPhpbFYQjJ93DUy2ufa5wM5PrvnuxwnCff4blM1vOORX6MUAIbuLh32Bfn76-GN1vbz5-nm9urpZGi7bsuRgXd8ykG3LRe96QQwWxpl-ELyzWnJBOJOSD5hrQ6mWjAjBCNG26y2jPVug9ZFrI2zVPvkdpIOK4NXfi5hGBal4E5yiQgOj0oLtBDdO9nbQ2DJohbDa4aGyPhxZ-1nvnDVuKgnCCfQ0M_mNGuOdIhj3gra4Et49EFL8Nbtc1M5n40J1zMU5K1q96CivUaVv_5Nu45xqF48qzNquNmaBLo8qk2LOyQ2PryFY3U-DOp2GWvDm6R8e5f-8Z38AM0SxXA</recordid><startdate>20230406</startdate><enddate>20230406</enddate><creator>Lim, Seojun</creator><creator>Oh, Sarang</creator><creator>Nguyen, Quynh T N</creator><creator>Kim, Myeongju</creator><creator>Zheng, Shengdao</creator><creator>Fang, Minzhe</creator><creator>Yi, Tae-Hoo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7SN</scope><scope>7SS</scope><scope>7T7</scope><scope>7X2</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M0K</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4802-1014</orcidid><orcidid>https://orcid.org/0000-0002-7818-0529</orcidid><orcidid>https://orcid.org/0000-0001-9369-6542</orcidid></search><sort><creationdate>20230406</creationdate><title>Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways</title><author>Lim, Seojun ; Oh, Sarang ; Nguyen, Quynh T N ; Kim, Myeongju ; Zheng, Shengdao ; Fang, Minzhe ; Yi, Tae-Hoo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-4ade953a855479e971c07cec9f746db847143884f04bc22b83177311bd69d3293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Allergic diseases</topic><topic>Allergies</topic><topic>allergy</topic><topic>Anaphylaxis</topic><topic>Anti-inflammatory agents</topic><topic>Antiviral activity</topic><topic>Asthma</topic><topic>Ca2+ influx</topic><topic>Calcium influx</topic><topic>Calcium ions</topic><topic>Calcium oxide</topic><topic>Calcium signalling</topic><topic>Cyclooxygenase-2</topic><topic>Cytokines</topic><topic>Degranulation</topic><topic>Dermatitis</topic><topic>Gene expression</topic><topic>Histamine</topic><topic>Histidine</topic><topic>Histidine decarboxylase</topic><topic>histidine decarboxylase (HDC)</topic><topic>Hypersensitivity</topic><topic>Immunoglobulin E</topic><topic>Inflammation</topic><topic>Interleukins</topic><topic>Kinases</topic><topic>Lipopolysaccharides</topic><topic>Macrophages</topic><topic>MAP kinase</topic><topic>Nitric oxide</topic><topic>Nitric-oxide synthase</topic><topic>Pathogenesis</topic><topic>Phosphorylation</topic><topic>Plant extracts</topic><topic>Prostaglandin endoperoxide synthase</topic><topic>Protein expression</topic><topic>Proteins</topic><topic>Rhinitis</topic><topic>Rosa davurica</topic><topic>Signal transduction</topic><topic>Signaling</topic><topic>Transcription factors</topic><topic>β-hexosaminidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lim, Seojun</creatorcontrib><creatorcontrib>Oh, Sarang</creatorcontrib><creatorcontrib>Nguyen, Quynh T N</creatorcontrib><creatorcontrib>Kim, Myeongju</creatorcontrib><creatorcontrib>Zheng, Shengdao</creatorcontrib><creatorcontrib>Fang, Minzhe</creatorcontrib><creatorcontrib>Yi, Tae-Hoo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Agricultural Science Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>ProQuest Biological Science Journals</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Open Access Journals</collection><jtitle>Plants (Basel)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lim, Seojun</au><au>Oh, Sarang</au><au>Nguyen, Quynh T N</au><au>Kim, Myeongju</au><au>Zheng, Shengdao</au><au>Fang, Minzhe</au><au>Yi, Tae-Hoo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways</atitle><jtitle>Plants (Basel)</jtitle><addtitle>Plants (Basel)</addtitle><date>2023-04-06</date><risdate>2023</risdate><volume>12</volume><issue>7</issue><spage>1572</spage><pages>1572-</pages><issn>2223-7747</issn><eissn>2223-7747</eissn><abstract>Pall. exhibits antioxidant, antiviral, and anti-inflammatory properties; however, its pharmacological mechanism in allergy is yet to be understood. This study confirmed the effects of
Pall. leaf extract (RLE) on allergy as a new promising material. To evaluate the therapeutic potential of RLE against allergy, we investigated the effects of RLE on the regulatory β-hexosaminidase, histamine, histidine decarboxylase (HDC), Ca
influx, nitric oxide (NO), and cytokines induced by lipopolysaccharide (LPS) and DNP-IgE/BSA in Raw 264.7 and RBL-2H3 cells. Furthermore, we examined the effects of RLE on the signaling pathways of mitogen-activated protein kinase (MAPK) and Ca
pathways. After stimulating Raw 264.7 cells with LPS, RLE reduced the release of inflammatory mediators, such as NO, cyclooxygenase (COX)-2, inducible nitric oxygen synthase (iNOS), interleukin (IL)-1β, -6, and tumor necrosis factor (TNF)-α. Also, RLE reduced the β-hexosaminidase, histamine, HDC, Ca
influx, Ca
pathways, and phosphorylation of MAPK in DNP-IgE/BSA-stimulated RBL-2H3 cells. Our studies indicated that RLE is a valuable ingredient for treating allergic diseases by regulating cytokine release from macrophages and mast cell degranulation. Consequently, these results suggested that RLE may serve as a possible alternative promising material for treating allergies.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37050198</pmid><doi>10.3390/plants12071572</doi><orcidid>https://orcid.org/0000-0003-4802-1014</orcidid><orcidid>https://orcid.org/0000-0002-7818-0529</orcidid><orcidid>https://orcid.org/0000-0001-9369-6542</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Plants (Basel), 2023-04, Vol.12 (7), p.1572 |
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| subjects | Allergic diseases Allergies allergy Anaphylaxis Anti-inflammatory agents Antiviral activity Asthma Ca2+ influx Calcium influx Calcium ions Calcium oxide Calcium signalling Cyclooxygenase-2 Cytokines Degranulation Dermatitis Gene expression Histamine Histidine Histidine decarboxylase histidine decarboxylase (HDC) Hypersensitivity Immunoglobulin E Inflammation Interleukins Kinases Lipopolysaccharides Macrophages MAP kinase Nitric oxide Nitric-oxide synthase Pathogenesis Phosphorylation Plant extracts Prostaglandin endoperoxide synthase Protein expression Proteins Rhinitis Rosa davurica Signal transduction Signaling Transcription factors β-hexosaminidase |
| title | Rosa davurica Inhibited Allergic Mediators by Regulating Calcium and Histamine Signaling Pathways |
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