The Employment of Genera Vaccinium , Citrus , Olea, and Cynara Polyphenols for the Reduction of Selected Anti-Cancer Drug Side Effects

Cancer is one of the most widespread diseases globally and one of the leading causes of death. Known cancer treatments are chemotherapy, surgery, radiation therapy, targeted hormonal therapy, or a combination of these methods. Antitumor drugs, with different mechanisms, interfere with cancer growth...

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Published in:Nutrients 2022-04, Vol.14 (8), p.1574
Main Authors: Maiuolo, Jessica, Musolino, Vincenzo, Gliozzi, Micaela, Carresi, Cristina, Oppedisano, Francesca, Nucera, Saverio, Scarano, Federica, Scicchitano, Miriam, Guarnieri, Lorenza, Bosco, Francesca, Macrì, Roberta, Ruga, Stefano, Cardamone, Antonio, Coppoletta, Anna Rita, Ilari, Sara, Mollace, Annachiara, Muscoli, Carolina, Cognetti, Francesco, Mollace, Vincenzo
Format: Article
Language:English
Subjects:
Adjuvants
Antineoplastic Agents - pharmacology
Antitumor activity
Apoptosis
Cancer
Cancer therapies
Carcinogenicity
Carcinogens
Cell cycle
Cell division
Chemotherapy
Cisplatin
Citrus
Clinical trials
Cynara
DNA methylation
Doxorubicin
Drugs
Employment
genera Vaccinium
Humans
Kinases
Metabolism
Metabolites
Mitochondrial DNA
Mutagenicity
Neoplasms - drug therapy
Olea
Paclitaxel
Polyphenols
Polyphenols - pharmacology
Polyphenols - therapeutic use
Proteins
Radiation
Radiation therapy
Review
Side effects
Small intestine
Teratogenicity
Tumors
Vaccinium
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Summary:Cancer is one of the most widespread diseases globally and one of the leading causes of death. Known cancer treatments are chemotherapy, surgery, radiation therapy, targeted hormonal therapy, or a combination of these methods. Antitumor drugs, with different mechanisms, interfere with cancer growth by destroying cancer cells. However, anticancer drugs are dangerous, as they significantly affect both cancer cells and healthy cells. In addition, there may be the onset of systemic side effects perceived and mutagenicity, teratogenicity, and further carcinogenicity. Many polyphenolic extracts, taken on top of common anti-tumor drugs, can participate in the anti-proliferative effect of drugs and significantly reduce the side effects developed. This review aims to discuss the current scientific knowledge of the protective effects of polyphenols of the genera , , , and on the side effects induced by four known chemotherapy, Cisplatin, Doxorubicin, Tamoxifen, and Paclitaxel. In particular, the summarized data will help to understand whether polyphenols can be used as adjuvants in cancer therapy, although further clinical trials will provide crucial information.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14081574