Signaling Nodes Associated with Endoplasmic Reticulum Stress during NAFLD Progression

Excess and sustained endoplasmic reticulum (ER) stress, paired with a failure of initial adaptive responses, acts as a critical trigger of nonalcoholic fatty liver disease (NAFLD) progression. Unfortunately, there is no drug currently approved for treatment, and the molecular basis of pathogenesis b...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2021-02, Vol.11 (2), p.242
Main Authors: Koo, Ja Hyun, Han, Chang Yeob
Format: Article
Language:English
Subjects:
Apoptosis
Autophagy
Endoplasmic reticulum
ER stress
Fatty liver
Gene expression
hepatic stellate cells
Hepatocytes
Homeostasis
Kinases
Kupffer cells
Lipids
Liver diseases
Metabolism
Nodes
nonalcoholic fatty liver disease
Phase transitions
Phosphorylation
Protein folding
Protein synthesis
Review
Transcription factors
unfold protein response
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Summary:Excess and sustained endoplasmic reticulum (ER) stress, paired with a failure of initial adaptive responses, acts as a critical trigger of nonalcoholic fatty liver disease (NAFLD) progression. Unfortunately, there is no drug currently approved for treatment, and the molecular basis of pathogenesis by ER stress remains poorly understood. Classical ER stress pathway molecules have distinct but inter-connected functions and complicated effects at each phase of the disease. Identification of the specific molecular signal mediators of the ER stress-mediated pathogenesis is, therefore, a crucial step in the development of new treatments. These signaling nodes may be specific to the cell type and/or the phase of disease progression. In this review, we highlight the recent advancements in knowledge concerning signaling nodes associated with ER stress and NAFLD progression in various types of liver cells.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom11020242