Engineering Fatty Acid Biosynthesis in Microalgae: Recent Progress and Perspectives

Microalgal lipids hold significant potential for the production of biodiesel and dietary supplements. To enhance their cost-effectiveness and commercial competitiveness, it is imperative to improve microalgal lipid productivity. Metabolic engineering that targets the key enzymes of the fatty acid sy...

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Bibliographic Details
Published in:Marine drugs 2024-05, Vol.22 (5), p.216
Main Authors: Song, Yanhui, Wang, Fangzhong, Chen, Lei, Zhang, Weiwen
Format: Article
Language:English
Subjects:
Algae
Animals
Aquatic microorganisms
Biodiesel fuels
Biofuels
Biosynthesis
Biosynthetic Pathways
Brain
Cardiovascular disease
Competitiveness
Dietary supplements
Energy minerals
Engineering
Enzymes
fatty acid biosynthetic pathway
Fatty acids
Fatty Acids - biosynthesis
Fatty Acids - metabolism
Fossil fuels
genetic engineering
Glycerol
Health aspects
Humans
lipid production
Lipids
Marine algae
Metabolic engineering
Metabolic Engineering - methods
Metabolism
Microalgae
Microalgae - metabolism
Phytoplankton
Production processes
Productivity
Regulatory mechanisms (biology)
Reviews
Synthesis
transcription factor
Transcription Factors - metabolism
transcriptional regulation
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Summary:Microalgal lipids hold significant potential for the production of biodiesel and dietary supplements. To enhance their cost-effectiveness and commercial competitiveness, it is imperative to improve microalgal lipid productivity. Metabolic engineering that targets the key enzymes of the fatty acid synthesis pathway, along with transcription factor engineering, are effective strategies for improving lipid productivity in microalgae. This review provides a summary of the advancements made in the past 5 years in engineering the fatty acid biosynthetic pathway in eukaryotic microalgae. Furthermore, this review offers insights into transcriptional regulatory mechanisms and transcription factor engineering aimed at enhancing lipid production in eukaryotic microalgae. Finally, the review discusses the challenges and future perspectives associated with utilizing microalgae for the efficient production of lipids.
ISSN:1660-3397
1660-3397
DOI:10.3390/md22050216