Antiproliferative Properties of Papaver rhoeas Ovule Extracts and Derived Fractions Tested on HL60 Leukemia Human Cells

plant is common in many regions worldwide and contributes to the landscape with its red flower. In the present study we first carried out morphological investigation by optical and scanning electron microscopy of the ovules within the ovary. After ovules' isolation we prepared extracts to test...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-04, Vol.25 (8), p.1850
Main Authors: Ovidi, Elisa, Laghezza Masci, Valentina, Garzoli, Stefania, Gambellini, Gabriella, Keita, Saran Vittoria, Zago, Daniele, Turchetti, Giovanni, Modesti, Lorenzo, Tiezzi, Antonio
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidants
Antiproliferatives
Biological activity
Cell Proliferation - drug effects
Chemical Fractionation
Chromatography
Chromatography, Thin Layer
cytotoxic activity
Cytotoxicity
Dose-Response Relationship, Drug
Ethanol
Fatty acids
Flowers & plants
Gas chromatography
Gas Chromatography-Mass Spectrometry
GC-MS
Herbal medicine
HL-60 Cells
Humans
Investigations
Leukemia
Mass spectrometry
Mass spectroscopy
Ovule - chemistry
Ovules
Papaver - chemistry
Papaver rhoeas
Pharmaceuticals
Plant cells
plant compounds
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Scanning electron microscopy
Sleep disorders
Statuary
Thin layer chromatography
Tumor cell lines
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Summary:plant is common in many regions worldwide and contributes to the landscape with its red flower. In the present study we first carried out morphological investigation by optical and scanning electron microscopy of the ovules within the ovary. After ovules' isolation we prepared extracts to test possible cytotoxic activities on HL60 leukemia human cells and investigated the extracts using thin-layer chromatography (TLC) and gas-chromatography/mass spectrometry (GC-MS). ovules showed an elongated, round shape and the presence of ordered sculptures on the ovule surface. The ovule extracts showed cytotoxic activity on HL60 human cells mainly found in some TLC-isolated spots. Compounds consisting of active spots were identified by GC-MS investigations. Our findings on the ovule compounds open perspectives for further investigations of TLC-isolated spots on other human cancer cell lines.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25081850