Prevalence and Clinical Significance of Subclinical Hypothyroidism in Diabetic Peripheral Neuropathy

Diabetic peripheral neuropathy (DPN) is one of the most common and disabling complications of DM. Many studies documented the prevalence of clinical and subclinical hypothyroidism (SCH) in diabetic patients but not in the particular group of patients with DPN. The present study aimed to determine th...

Full description

Saved in:
Bibliographic Details
Published in:International journal of general medicine 2021-01, Vol.14, p.7755-7761
Main Authors: Allam, Mahmoud A, Nassar, Youssef A, Shabana, Hosameldeen S, Mostafa, Sadek, Khalil, Farag, Zidan, Hendawy, Abo-Ghebsha, Mohammed, Abdelghaffar, Amir, Essmat, Ahmed, Elmahdi, Essam
Format: Article
Language:English
Subjects:
Clinical significance
Diabetes
diabetes mellitus
diabetic peripheral neuropathy
Diabetics
Disease
Fasting
Glycosylated hemoglobin
Health aspects
Hyperglycemia
Hypothyroidism
Insulin resistance
Laboratories
Medical research
Medicine, Experimental
Original Research
Oxidative stress
Pathogenesis
Peripheral neuropathy
Regression analysis
subclinical hypothyroidism
thyroid dysfunction
Thyroid gland
thyroid hormones
Thyroxine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Diabetic peripheral neuropathy (DPN) is one of the most common and disabling complications of DM. Many studies documented the prevalence of clinical and subclinical hypothyroidism (SCH) in diabetic patients but not in the particular group of patients with DPN. The present study aimed to determine the prevalence of SCH in DPN patients and to evaluate its association with severity of DPN. The present cross-sectional study was conducted on 300 consecutive patients with DPN. The clinical manifestations of DPN were documented according to the validated Arabic version of the Michigan Neuropathy Screening Instrument. Severity of DPN was categorized into mild (6-8 points), moderate (9-11 points) or severe (12+ points) according to the Toronto Clinical Scoring System. All patients were submitted to careful history-taking and full clinical and neurological examination. Patients were diagnosed with SCH if they had TSH level above the upper limit of the normal reference range in association with normal free thyroxine (FT4) level. SCH was prevalent in 53 patients (17.7%, 95% CI: 13.5%-22.5%). Patients with SCH had significantly higher frequency of severe DPN (52.8% versus 28.3%, =0.003). It was also shown that patients with SCH had significantly higher HbA1c (8.4 ± 1.0 versus 7.3 ± 1.2%,
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S337779