Strategies to Mitigate and Treat Orthopaedic Device-Associated Infections

Orthopaedic device implants play a crucial role in restoring functionality to patients suffering from debilitating musculoskeletal diseases or to those who have experienced traumatic injury. However, the surgical implantation of these devices carries a risk of infection, which represents a significa...

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Bibliographic Details
Published in:Antibiotics (Basel) 2022-12, Vol.11 (12), p.1822
Main Authors: Kennedy, Darragh G, O'Mahony, Aoife M, Culligan, Eamonn P, O'Driscoll, Caitriona M, Ryan, Katie B
Format: Article
Language:English
Subjects:
Analysis
Antibacterial activity
Antibiotics
Antimicrobial agents
Bacteria
biofilm
Biofilms
bioinspired
drug delivery
Drug resistance
Foreign bodies
Fractures
Health aspects
Health risks
Hospital costs
Immune system
implant coating
Implants, Artificial
Infection
Infections
Joint replacement surgery
Medical devices
Medical equipment
Medical research
Methicillin
Musculoskeletal diseases
Orthopaedic implants
Orthopedic apparatus
Orthopedic equipment and supplies
Orthopedics
Pathogenesis
Pathogens
Patients
Prostheses
Prosthesis
Review
Staphylococcus infections
Surface chemistry
Transplants & implants
Virulence
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Summary:Orthopaedic device implants play a crucial role in restoring functionality to patients suffering from debilitating musculoskeletal diseases or to those who have experienced traumatic injury. However, the surgical implantation of these devices carries a risk of infection, which represents a significant burden for patients and healthcare providers. This review delineates the pathogenesis of orthopaedic implant infections and the challenges that arise due to biofilm formation and the implications for treatment. It focuses on research advancements in the development of next-generation orthopaedic medical devices to mitigate against implant-related infections. Key considerations impacting the development of devices, which must often perform multiple biological and mechanical roles, are delineated. We review technologies designed to exert spatial and temporal control over antimicrobial presentation and the use of antimicrobial surfaces with intrinsic antibacterial activity. A range of measures to control bio-interfacial interactions including approaches that modify implant surface chemistry or topography to reduce the capacity of bacteria to colonise the surface, form biofilms and cause infections at the device interface and surrounding tissues are also reviewed.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics11121822