Transcranial Alternating Current Stimulation: A Potential Risk for Genetic Generalized Epilepsy Patients (Study Case)

Transcranial alternating current stimulation (tACS) is a re-emergent neuromodulation technique that consists in the external application of oscillating electrical currents that induces changes in cortical excitability. We present the case of a 16-year-old female with pharmaco-resistant juvenile myoc...

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Bibliographic Details
Published in:Frontiers in neurology 2016-11, Vol.7, p.213
Main Authors: San-Juan, Daniel, Sarmiento, Carlos Ignacio, Hernandez-Ruiz, Axel, Elizondo-Zepeda, Ernesto, Santos-Vázquez, Gabriel, Reyes-Acevedo, Gerardo, Zúñiga-Gazcón, Héctor, Zamora-Jarquín, Carol Marina
Format: Article
Language:English
Subjects:
adverse events
generalized epilepsy
Neuromodulation
Neuroscience
Status Epilepticus
transcranial alternating current stimulation (tACS)
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Summary:Transcranial alternating current stimulation (tACS) is a re-emergent neuromodulation technique that consists in the external application of oscillating electrical currents that induces changes in cortical excitability. We present the case of a 16-year-old female with pharmaco-resistant juvenile myoclonic epilepsy to 3 antiepileptic's drugs characterized by 4 myoclonic and 20 absence seizures monthly. She received tACS at 1 mA at 3 Hz pulse train during 60 min over Fp1-Fp2 (10-20 EEG international system position) during 4 consecutive days using an Endeavor™ IOM Systems device (Natus Medical Incorporated, Middleton, WI, USA). At the 1-month follow-up, she reported a 75% increase in seizures frequency (only myoclonic and tonic-clonic events) and developed a 24-h myoclonic status epilepticus that resolved with oral clonazepam and intravenous valproate. At the 2-month follow-up, the patient reported a 15-day seizure-free period.
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2016.00213