Mycobacterial spindle cell pseudotumor of the appendix vermiformis in a patient with aids

Mycobacterial pseudotumor (MP) is a rare pathologic presentation of both Mycobacterium tuberculosis and non-tuberculous mycobacterial disease, hitherto reported to occur only in immunosuppressed patients with or without human immunodeficiency virus infection. This lesion shares close pathologic rese...

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Bibliographic Details
Published in:The Brazilian journal of infectious diseases 2001-04, Vol.5 (2), p.98-100
Main Authors: Basilio-de-Oliveira, C, Eyer-Silva, W A, Valle, H A, Rodrigues, A L, Pinheiro Pimentel, A L, Morais-De-Sá, C A
Format: Article
Language:English
Subjects:
Adult
AIDS-Related Opportunistic Infections - diagnosis
AIDS-Related Opportunistic Infections - microbiology
AIDS-Related Opportunistic Infections - pathology
Appendix - microbiology
Diagnosis, Differential
Fatal Outcome
HIV infection
HIV Infections - complications
Humans
Immunocompromised Host
INFECTIOUS DISEASES
Kaposi's sarcoma
Lymph Nodes - pathology
Male
Mycobacterium
Mycobacterium avium-intracellulare Infection - diagnosis
Mycobacterium avium-intracellulare Infection - microbiology
Mycobacterium avium-intracellulare Infection - pathology
pseudotumor
Sarcoma, Kaposi - diagnosis
Sarcoma, Kaposi - microbiology
Sarcoma, Kaposi - pathology
spindle cell
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Description
Summary:Mycobacterial pseudotumor (MP) is a rare pathologic presentation of both Mycobacterium tuberculosis and non-tuberculous mycobacterial disease, hitherto reported to occur only in immunosuppressed patients with or without human immunodeficiency virus infection. This lesion shares close pathologic resemblance to certain mesenchymal neoplasms, particularly Kaposi's sarcoma (KS), from which it must be properly differentiated due to distinct prognosis and therapy. We report a case of MP obliterating the lumen of the appendix vermiformis in a 34-year-old patient who died of complications of AIDS at our hospital in Rio de Janeiro. A total of 24 cases of MP (including our patient) have been described in the literature. MP has been found especially in lymph nodes, but extranodal lesions have been described in the skin, spleen, lung, bone marrow, brain and, in our patient, the appendix vermiformis. We offer a review of the other 23 published case reports of MP in both HIV-infected and uninfected patients and discuss the pathologic features that differentiate MP from KS.
ISSN:1413-8670
1678-4391
1413-8670
1678-4391
DOI:10.1590/S1413-86702001000200008